Morphological criteria for periodization of spine development
The objective of the research was to study morphogenetic criteria for periodization of spine development in ontogenesis. The subject of the study was vertebral bodies of 50 mini pigs in the postnatal period (newborn, two-week-old, one-month-old, three-month-old, and six-month-old piglets). It was found that vertebral bodies develop in two stages. Stage 1 involves early osteogenesis from birth till one month of age, which is a period of intense chondroblast proliferation and differentiation around the vertebral body perimeter due to a circular growth zone. During this period, vertebral body cartilage metabolism is mediated by vessels. Growth control is associated with the blood-cartilage barrier restraining osteogenesis, stimulating cell proliferation and differentiation by maintaining the homeostasis of cells and the matrix. Stage 2 involves linear growth, which is characterized by decreased proliferation and intensified synthetic processes that are followed by differentiation of chondroblasts into chondrocytes. This period of development is associated with the formed cartilage growth plate contributing to the longitudinal development of the vertebral body.
About Authors (Correspondence):
Zaidman A.M. – doctor of medical sciences, professor, head of laboratory of pathomorphology and theoretical research in vertebrology, honored scientist of the RF, e-mail: AZaidman@niito.ru
Korel A.V. – candidate of biological sciences, senior researcher of the laboratory of pathomorphology and theoretical research in vertebrology, e-mail: AKorel@niito.ru
Strokova E.L. – researcher of laboratory of pathomorphology and theoretical research in vertebrology, e-mail: EZavyalova@niito.ru