The Siberian Scientific Medical Journal
 
 
№ 2 / 2016 / 24-28

Research of the allergenic properties of new silver containing finely particulate sorbent

Author Affiliations

Abstract

The aim was to research the allergenic activity of silver containing finely particulate sorbent. Materials and methods. For the study we used novel excipient, consisting of two components: silver containing finely particulate sorbent and chitosan gel in ratio of one-to-one. The novel sorbent agent consists of thermally activated silica containing aluminum hydroxide modified with silver. The experiment was conducted on 32 Wistar female rats using skin application and conjunctival samples. The results. Silver containing finely particulate sorbent does not show negative allergenicity properties at skin application and conjunctival samples. Thus, it is concluded that the developed silver containing finely particulate sorbent does not cause any allergic reactions at skin application and conjunctival samples and can be recommended as an active pharmaceutical ingredient for external medical or cosmetic products.

Key words

allergy, conjunctival sample, cutaneous test, silver-sorbents
References
About Authors (Correspondence):

Popova T.V. – postgraduate student, e-mail: argentum.popova@mail.ru

Tolstikova T.G. – doctor of biological sciences, head of the laboratory of pharmacological investigation, professor

Letyagin A.Yu. – doctor of medical sciences, professor, leading researcher of laboratory for lympharegulation, e-mail: letyagin-andrey@yandex.ru

Rachkovskaya L.N. – candidate of chemical sciences, head of the laboratory of biological active compounds

Full Text

Received: 19/05/2016