The Siberian Scientific Medical Journal
 
 
№ 6 / 2014 / 17-26

Mesenchymal stromal cells in aplastic anemia, hematological malignancies and not hematological tumors

Author Affiliations

Abstract

The results of the study on mesenchymal stromal cells (MSC) in aplastic anemia (AA), hemoblastosis and not hematological tumors have been analyzed. The data testifying for the involvement of hematopoietic niches in the pathological process in AA and hematological malignancies as well as the facts confirming that the elements of the microenvironment can be the original cause of hematological diseases have been given.. The analysis of the results of study on the MSC influence on the tumor growth and metastasis has been carried out. The inconsistency of obtained data has been noted. It is shown that MSC can have both stimulating and inhibiting effect, possible mechanisms underlying these processes are discussed. It has been concluded that the better understanding of the MSC biology and their role in the onset and progression of various pathological conditions can become the basis for the development of new programs for the treatment of hematological and oncological diseases.

Key words

aplastic anemia (AA), hemoblastosis, hematopoietic niche, carcinogenesis, mesenchymal stromal cells (MSC), stroma of bone marrow
References
About Authors (Correspondence):

Vartanyan N.L. – candidate of biological sciences, senior researcher of laboratory of hybridoma technology, e-mail: nvartanian@mail.ru.

Bessmeltsev S.S. – doctor of medical sciences, professor, deputy director on scientific work, e-mail: bsshem@hotmail.com.

Semenova N.Yu. – biologist, junior researcher of laboratory for the study of leukemia, e-mail: bloodscience@mail.ru

Rugal V.I. – doctor of medical sciences, professor, head of laboratory for the study of leukemia

Full Text

Received: 07/02/2015
Accepted: 11/05/2015