Мезенхимальные стромальные клетки при апластической анемии, гемобластозах и негематологических опухолях
Реферат
В обзоре проанализированы результаты изучения мезенхимальных стромальных клеток (МСК) при апластической анемии (АА), гемобластозах и негематологических опухолях. Приведены данные, свидетельствующие о вовлечении гемопоэтической ниши в патологический процесс при АА и гемобластозах, а также факты, подтверждающие, что элементы микроокружения могут быть первопричиной возникновения гематологических заболеваний. Проведен анализ результатов изучения влияния МСК на рост и метастазирование опухолей, отмечена противоречивость полученных данных. Показано, что МСК могут оказывать как стимулирующий, так и ингибирующий эффект, обсуждаются возможные механизмы, лежащие в основе этих процессов. Делается вывод, что более глубокое понимание биологии МСК и их роли в возникновении и прогрессировании различных патологических состояний может стать основой для разработки новых программ лечения гематологических и онкологических заболеваний
Тэги
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Вартанян Н.Л. – к.б.н., старший научный сотрудник лаборатории гибридомной технологии, e-mail: nvartanian@mail.ru
Бессмельцев С.С. – д.м.н., проф., зам. директора по научно-исследовательской работе, e-mail: bsshem@hotmail.com
Семенова Н.Ю. – биолог, младший научный сотрудник лаборатории по изучению лейкозов, e-mail: bloodscience@mail.ru
Ругаль В.И. – д.м.н., проф., руководитель лаборатории по изучению лейкозов
