№ 2 / 2016 / 50-55

Blood serum and peritoneal fluid cytokines concentrations in women with infertility and chronic inflammation of reproductive system

Author: Trunovа L.A.¹, Marinkin I.O.², Trunov A.N.³, Kuleshov V.M.⁴, Obukhovа O.O.⁵, Gorbenko O.M.⁶, Shvayuk A.P.⁷

Abstract

The purpose of the study was to investigate blood and peritoneal fluid concentrations of cytokines in women with infertility and chronic infectious inflammation (CII) of reproductive system. 65 patients were included in the study: 50 patients were diagnosed as tubal and peritoneal infertility and CII of reproductive system in remission; 15 patients were almost healthy women of comparable age. The concentrations of TNF-α, IL-4, IL-6, IFNγ, MCP-1 and sVCAM-1 were measured in blood serum and peritoneal fluid. Permanent activation of local inflammation and immune reactions activation found in clinical remission of CII have been shown to play an important role in the pathogenesis of infertility associated with CII of reproductive system. It was proven by the increase of the concentrations of inflammatory cytokines (IL-6, MCP-1, and sVCAM-1) and inductors of Th1 and Th2 pathways. The concentration of TNF-α was increased in peritoneal fluid and was within normal range in blood serum in women of the study group. Based on the results of our study we believe that chronic inflammation of reproductive system and associated cytokines imbalance may play a role in tubal and peritoneal infertility pathogenesis.

Key words

infertility, immune response, chronic inflammation, cytokines

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About Authors (Correspondence):

Trunovа L.A. – doctor of medical sciences, professor, corresponding member of RAS, chief researcher of the laboratory of immunology

Marinkin I.O. – doctor of medical sciences, professor, head of the department of obstetrics and gynecology, e-mail. reсtorngmu@yandex.ru

Trunov A.N. – doctor of medical sciences, professor, head of the laboratory of immunology of reproduction, e-mail: trunov1963@yandex.ru

Kuleshov V.M. – doctor of medical sciences, professor of department of obstetrics and gynecology, e-mail. kuleshov_vm@mail.ru

Obukhovа O.O. – doctor of medical sciences, leading researcher of the laboratory of immunology, e-mail: olga.o.obukhova@gmail.com

Gorbenko O.M. – candidate of medical sciences, senior researcher of the laboratory of immunology, e-mail: gorbenko1956@yandex.ru

Shvayuk A.P. – candidate of medical sciences, senior researcher of the laboratory of immunology, e-mail: alevtina.shvayuk@yandex.ru

Full Text

8-2-2016.pdf

Received: 19/05/2016