Immunological profile of patients with delayed bone tissue consolidation at long term after closed long bone injuries
Author Affiliations1Russian Scientific Center for Restorative Traumatology and Orthopaedics n.a. Ilizarov of Minzdrav of Russia 640014, Kurgan, Mariya Ulyanova str., 6
2Russian Scientific Center for Restorative Traumatology and Orthopaedics n.a. Ilizarov of Minzdrav of Russia 640014, Kurgan, Mariya Ulyanova str., 6
3Russian Scientific Center for Restorative Traumatology and Orthopaedics n.a. Ilizarov of Minzdrav of Russia 640014, Kurgan, Mariya Ulyanova str., 6
Abstract
Immunity parameters were studied in the period from 350 to 420 days after a closed long bone fracture treated with the Ilizarov method of transosseous osteosynthesis in patients with delayed bone union (n = 17) and fracture consolidation in optimal time periods (n = 20). The main parameters of cell and humoral immunity were within the limits of physiological norms in cases of normal reparative activity of the bone tissue. There was a tendency to the increase in IL-8 and Il-6 concentrations. The values of stimulated NBT test were increased. Delayed bone tissue consolidation was characterized by moderate activation of cell immunity along with increase in TNFα, decrease in CD14+HLA-DR expression, enhanced oxygen-dependent and oxygen-independent bactericidal activity of neutrophils, and neutrophil ability to form neutrophil extracellular traps.
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References
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About Authors (Correspondence):
Chepeleva M.V. – candidate of medical sciences, senior researcher of clinical laboratory of microbiology and immunology, e-mail: Vladi_2000@hotbox.ru
Kuznetsova E.I. – junior researcher of clinical laboratory of microbiology and immunology, e-mail: citoz@mail.ru
Karasev A.G. – doctor of medical sciences, associate professor, senior researcher of scientific-and-clinical laboratory of traumatology, e-mail: office@ilizarov.ru