Prognosis of venous thromboembolic complications after the hip joints endoprothesis replacement againts the background of modernt thromboprophylaxis
Author Affiliations1Federal Center of Traumatology, Orthopedy and Endoprothesing of Minzdrav of Russia, 656045, Barnaul, Lyapidevski str., 1/3
2Altai State Medical University of Minzdrav of Russia, 656045, Barnaul, Lenin av., 40; Hematology Scientific Center of Minzdrav of Russia, Altai Branch, 656045, Barnaul, Lyapidevski str., 1
3Altai State Medical University of Minzdrav of Russia, 656045, Barnaul, Lenin av., 40
4Altai State Medical University of Minzdrav of Russia, 656045, Barnaul, Lenin av., 40
Abstract
The research aim is to determine sufficient factors of thrombogenic risk (TR) of post operative venous thromboembolic complications (VTC) development against the background of modern thromboprophylaxis including non-pharmacological and pharmacological implications. Materials and methods. The observation data of 351 patients underwent the primary total hit joint endoprothesis replacement have been presented. The patient interview and medical documentation researching, some laboratory analyses including genetical study have been carried out to reveal the potential factors of TR. Results. Six TR factors among considered 27 that significantly increased the possibility of VTC incurrence have been determined. There are diabetes mellitus of 2 type (odd ratio OR 5,6; 95% confident interval CI 1.8–17.0), female sex belonging (OR 4.6; CI 1.5–13.6), physical activity low level (OR 4.4; CI 1.7–11.1), age over 60 (OR 4.3; CI 1.8–10.6), increased level of D-dimers straight before operation (OR 3.5; CI 1.4–8.9) and low extremities varicose disease (OR 3.4; CI 1.5–7.7). Conclusion. Revealed TR factors allow to determine the group of VTC high risk after the hit joint endoprothesis replacement and to develop approaches to the individual thromboprophylaxis among these patients category.
Key words
References
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About Authors (Correspondence):
Berezhnyak I.V. – anaesthesiologist, e-mail: iv1378@yandex.ru
Momot A.P. – doctor of medical sciences, director, е-mail: xyzan@yandex.ru
Merkulov I.V. – doctor of medical sciences, professor of the chair for anesthesiology and intensive care medicine, е-mail: aandrtech@rambler.ru
Osipova I.V. – doctor of medical sciences, professor of the chair for faculty therapy, occupational diseases with the course of clinical pharmacology, chief specialist on prophylactic medicine of Altai district, е-mail: i.v.osipova@gmail.com
