Early vascular aging. Nowadays status of the problem
Author Affiliations
1Dpt of Clinical Sciences Lund University, Malmö, Sweden, IM Nilssons gata 32, 2nd floor Skåne University Hospital S-205 02 MALME SWEDEN
2Novosibirsk Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Novosibirsk Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
Abstract
For a number of years research dedicated to understand atherosclerosis dominated, and for many good reasons as this pathophysiological process is proximal to the CVD. In recent years, research has been devoted to an earlier stage of vascular pathology (arteriosclerosis) and the new concept of Early Vascular Ageing (EVA) that has been developed by a group of mostly European researchers. The genetic aspects of EVA-syndrome, telomere biology, systemic inflammation, arterial stiffness measurement direct and indirect methods are at great focus of interest. There are still no unifying EVA treatment methods, only recommendations for conventional cardiovascular risk factor control. New interventions are being developed, not only new antihypertensive drugs but also new drugs for vascular protection, i.e. the selective Angiotensin-II (AT2) agonist named Compound 21 (C21). Human studies are awaited.
Key words
vascular ageing, hypertension, CAD, arteriosclerosis, arterial stiffness, metabolic syndrome, telomeres, matrix metalloproteinase
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About Authors (Correspondence):
Nilsson Peter M. – professor of cardiovascular research, consultant, e-mail: peter.nilsson@med.lu.se
Yakhontov D.A. – doctor of medical sciences, e-mail: mich99@mail.ru
Ostanina Yu.O. – postgraduate student, e-mail: Julia679@yandex.ru
Received: 08/11/2016
