Clinical nutritional and metabolic peculiarities of comorbid phenotype of chronic obstructive pulmonary disease and arterial hypertension

The comprehensive assessment of clinical nutritional status of patients with chronic obstructive pulmonary disease combined with arterial hypertension, including the study of diurnal profile of arterial pressure, indicators of function of external respiration, protein, lipid and carbohydrate metabolism, body composition component of patients and assessment of the profile of adipokines and cytokines have been carried out. The marked decrease of respiratory function, increased prevalence of non-dippers, defined by increase in fat mass and extracellular fluid due to deficit of lean mass and decreasing phase angle, proatherogenic dyslipidemia, protein deficiency, carbohydrate metabolism disorders, high level adipocytokines activity have been revealed in this group. The features of nutritional status with comorbid version of the disease have been described. The most informative, integral indicators of nutritional disorders in this phenotype – index waist circumference/hip circumference and lean mass have been selected. The additional markers for diagnosis of nutritional disorders with co-morbid chronic obstructive pulmonary disease and hypertension have been developed.