Late bronchial asthma: clinical, functional and immunological features
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
4Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
5Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
Abstract
452 patients with bronchial asthma were subjected to clinical-functional and immunological check-up. All of them were divided into two groups: the first group – 286 patients with the beginning of disease development after the age of 40, i.e. people with late asthma, second group – 166 persons with bronchial asthma beginning before the age of 40. It has been shown that the late asthma has severer, unstable course and atypical clinical manifestation. Eosinophilic, neutrophilic inflammation is the specific marker of late asthma. The revealed immunological peculiarities of late asthma help to make the diagnosis and to differentiate late asthma from early forms of disease. Diagnostic and prognosis markers of late asthma were developed. The treatment programs considering the clinical and immunology peculiarities have been elaborated.
Key words
References
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About Authors (Correspondence):
Kudelya L.M. – doctor of medical sciences, professor, honored physician of the RF, head of pulmonary department, professor of the internal diseases chair, chief pulmonologist of the Novosibirsk region, e-mail: Oxy80@mail.ru
Sidorova L.D. – doctor of medical sciences, professor, academician of RAS, honored scientist, professor of the internal diseases chair
Mozhina L.N. – candidate of medical sciences, associate professor of the internal diseases chair
Tikhomirova E.G. – candidate of medical sciences, associate professor of internal diseases chair
Manzhileeva T.V. – candidate of medical sciences, assistant of internal diseases chair
