The predictive value of hyperferritinemia in newly diagnosed patients with lymphoma
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52; City Novosibirsk Municipal Hospital № 2, 630051, Novosibirsk, Polzunov str., 21
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52; City Novosibirsk Municipal Hospital № 2, 630051, Novosibirsk, Polzunov str., 21
3Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
Abstract
The increasing level of ferritin in serum blood without iron overload has been described in cancer. The iron dismetabolism, particularly hyperferritinemia, is the promoter of cancer progression and may have a predictive value. Aim of study: to assess of predictive value of hyperferritinemia as a marker of poor prognosis in newly diagnosed patients with lymphoma. Material and methods. A total of the 98 newly diagnosed patients were included in study, which was performed in 2012-2014. Results. The level of ferritin was elevated in 61.22 % patients. Role of ferritin as acute phase reactant was confirmed (p < 0.05), and it was more valuable marker than lactate dehydrogenase and C-reactive protein (OR 3.3, C.I. [3.024–10.668], p < 0.05). Furthermore, our findings have shown, that hyperferritinemia in newly diagnosed lymphoma patients is associated with decreasing of overall survival (p = 0.004) and increasing mortality risk (OR 8.122; C.I. [1.764–7.396]; р < 0.05).
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References
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About Authors (Correspondence):
Babaeva T.N. – assistant professor of the chair for therapy, haematology and transfusiology, e-mail: babaeva_tatyana@mail.ru
Pospelova T.I. – doctor of medical sciences, professor, head of the chair for therapy, haematology and transfusiology, e-mail: post_gem@mail.ru
Seregina O.B. – assistant professor of the chair for therapy, haematology and transfusiology, e-mail: post_gem@mail.ru
