Frequency and structure of comorbid conditions in patients with multiple myeloma according to city hematology center of Novosibirsk
Abstract
206 patients with multiple myeloma (MM) have been examined. Mean age of patients was 68 years. The IIIA stage of the disease, the second and bigger somatic status by ECOG were diagnosed in majority of patients. The incidence and structure of comorbid conditions and their influence on complications development and therapy results as well as on patient survival rate have been evaluated. Prevalence of comorbidity in patients with MM at diagnosis was 80 %. The diseases of gastrointestinal tract (88.4 %), cardiovascular system (78.6 %), urinary tract (44.5 %), and endocrine systems (26.8 %) took the main place in the structure of comorbid conditions. Occurrence of comorbidities was associated with the lower frequency value and the worst clinical response to standard therapy of I and II lines, as well as with the development of significantly bigger number of gastrointestinal and infectious side effects of chemotherapy. Analysis of overall survival in patients with MM depending on the presence or absence of comorbid conditions showed the significant decrease of this index in the group of patients with the presence of comorbidities.
Key words
ReferencesSkvortsova N.V. – candidate of medical sciences, assistant of the chair for therapy, hematology and transfusiology, e-mail: nata_sk78@mail.ru
Pospelova T.I. – doctor of medical sciences, professor of the chair for therapy, hematology and transfusiology, e-mail: post_gem@mail.ru
Kovynev I.B. – doctor of medical sciences, professor of the chair for therapy, hematology and transfusiology, e-mail: post_gem@mail.ru
Nechunaeva I.N. – candidate of medical sciences, head of the department of hematology, e-mail: post_gem@mail.ru
