The Siberian Scientific Medical Journal
№ 6 / 2016 / 80-84

Pharmacological responses in patients with different etiology of restless legs syndrom

Author Affiliations


The effectiveness of pharmacological responses in patients with different restless legs syndromes (RLS): idiopathic, family and neuropathic forms was evaluated. 139 patients with RLS were included into research. They were divided into 3 groups: 67 patients with family RLS, 46 patients with idiopathic RLS, and 26 patients with neuropathic RLS. All patients were administrated drugs: mirapex (pramipexol), madopar (levodopa+benserosid), benzodiazepines (lorazepam, clonazepam), opioid (tramadol), antidepressant (trittico), miorealaxant (baclofen). Medications have been taken in terns. Every two weeks one of the medications was substituted into another one. The evaluation of pharmacological response to every above mentioned drugs have been carried out according to the scale of Relative Global Assessment Scale (RGAS) two weeks later by the end of administration of each drug. The data were compared for effectiveness of the response in the comparison groups. Madopar and mirapex proved more effective than clonazepam, lorazepam tramadol within each group (p < 0,01). No significant differences in efficacy between Madopar mirapex and in the treatment of RLS has been detected (p > 0,05). Conclusion. The most effective drugs against RLS were mirapex, madopar. These drugs are the first choice in the treatment of RLS. Clonazepam, Lorazepam and tramadol were less effective. The antidepressants trittiko and miorealaksanta baclofen did not demonstrated any positive effects.

Key words

baclofen, clonazepam, lorazepam, madopar, mirapex, restless legs syndrome, tramadol, trittico
About Authors (Correspondence):

Abramovskikh L.E. – postgraduate student, neurologist, е-mail:

Pilipenko P.I. – doctor of medical sciences, professor, head of department, е-mail:

Vostrikova E.V. – candidate of medical sciences, associate professor, head of regional specialized scientific and practical neurological center, е-mail:

Received: 27/12/2016