The features of stress-induced changes of the heart rhythm, erythrocytes adrenoreactivity and free radicals processes in blood on the background of stimulation of central neurotransmitter systems
Author Affiliations1Astrakhan State University, 414000, Аstrakhan, Schaumyan sq., 1
2Astrakhan State University, 414000, Аstrakhan, Schaumyan sq., 1
3Astrakhan State University, 414000, Аstrakhan, Schaumyan sq., 1
4Astrakhan State University, 414000, Аstrakhan, Schaumyan sq., 1
Abstract
In the work there were studied the indexes of the heart rhythm variability (HRV) and erythrocytes β-adrenoreactivity (β-EAR), the level of lipid peroxidation products, the blood catalase activity of non-linear male rats along with their changes in reaction to acute stress while background of the neurotransmitter systems activation through injecting of the preparations: noradrenergic system (NAS) – maprotiline (10 mg/kg), serotonergic system (SRS) – 5 hydroxytryptophan (50 mg/kg) and fluoxetine (3 mg/kg), dopaminergic system (DFS) – L-dopa and amantadine (20 mg/kg). The increase of HRF, stress index (SI), the power fall in HRV waves spectrum, the growth of β-EAR as well as reducing the background of TBA-reactive substances level in plasma of intact rats have been revealed in varying degrees in all series with stimulation of neurotransmitter systems (in particular SRS). The reaction to the acute stress is close to the control in rats with stimulation NAS, but showing a sharp increase of HRF, SI, decrease of HRV waves power and the β-EAR under small shifts in blood free radical balance. The reaction to the stress at rats with the stimulated SRS and DFS is different from the control and causes the decrease in HRF and SI. High rigidity of heart rate corresponds to high β-EAR and increasing level of TBA-reactive substances in plasma at the activation of SRS, and high heart rhythm variability corresponds to both decreases in β-EAR and blood catalase activity at the activation of DFS. Thus, the stimulation of neurotransmitter systems significantly modifies the HRV, β-EAR and blood free radical balance at rest and stress-induced changes, and is noticed as some similarities and marked specificity of the each neurotransmitter effects systems activation.
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References
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About Authors (Correspondence):
Kuryanova E.V. – doctor of biological sciences, professor of the chair for physiology, morphology, genetic and biomedicine, e-mail: fyzevk@rambler.ru
Tryasuchev A.V. – postgraduate student of the chair for physiology, morphology, genetic and biomedicine, е-mail: tryndval@mail.ru
Stupin V.O. – postgraduate student of the chair for physiology, morphology, genetic and biomedicine, е-mail: neverforgettoday@bk.ru
Teply D.L. – doctor of biological sciences, professor, head of the chair for physiology, morphology, genetic and biomedicine, e-mail: physiology-agu@mail.ru
