№ 1 / 2017 / 41-47

The role of individual risk factors in the formation of peculiarities of the main forms of occupational diseases in the post-exposure period

Author: Poteryaeva E.L.¹, Smirnova E.L², Maksimov V.N.³, Kolesnik K.N.⁴, Nikiforova N.G.⁵, Peskov S.A.⁶

Abstract

The analysis of genetic molecular and biochemical markers of early development and unfavorable course of vibration disease and pneumoconiosis in the post-exposure period has been presented. The results of study of frequencies of genotypes and alleles of the polymorphism rs11562975 TRPM8 gene, rs1801133 (C677T) of the MTHFR gene, I/D polymorphism (rs28365031) ADRA2B gene and VNTR (4b/4a) polymorphism in the 4th intron of the gene NOS3 in patients with early and late time-line of vibration disease development have been performed. The analysis of frequency of occurrence of genotypes and alleles I/D of CCR5 gene polymorphism, 4a/b polymorphism of NOS3 gene, VNTR polymorphism of IL1RN gene, I/D polymorphism CASP8 and mutations GLU342LYS (rs28929474) and GLU264VAL (rs17580) in gene SERPINA1 in patients with different timing of pneumoconiosis formation has been carried out. The individual criteria for pneumoconiosis early forming and progression in the post-exposure period have been determined.

Key words

occupational disease, vibration disease, pneumoconiosis, gene polymorphism, genetic molecular markers

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About Authors (Correspondence):

Poteryaeva E.L. – doctor of medical sciences, professor, head of the chair of emergency therapy with endocrinology and occupational pathology, head of department of occupational medicine, e-mail: sovetmedin@yandex.ru

Smirnova E.L. – candidate of medical sciences, associate professor of the chair for urgent therapy with endocrinology and occupational pathology, senior researcher, e-mail: кafprofpat@mail.ru

Maksimov V.N. – doctor of medical sciences, professor of medical genetics and biology, head of laboratory of molecular genetic studies of therapeutic diseases, e-mail: medic11@mail.ru

Kolesnik K.N. – junior researcher of laboratory of molecular genetic studies of therapeutic diseases, e-mail: ksenya-kolesnik@mail.ru

Nikiforova N.G. – doctor of biological sciences, professor, head of department of hygiene and ecology, senior researcher, e-mail: sovetmedin@yandex.ru

Peskov S.A. – doctor of medical sciences, professor of department of hygiene and ecology, e-mail: sovetmedin@yandex.ru

Received: 15/02/2017