Age and gender features of non-alcoholic fatty liver disease
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
5Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
6Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
7Novosibirsk State Medical University of Minzdrav of Russia, 630091 Novosibirsk, Krasny av., 52
Abstract
The purpose of the study. Evaluation of clinical course and metabolic disorders in men and women with non-alcoholic fatty liver disease (NAFLD) of different ages. Materials and methods. 113 patients (63 men and 50 women) have been examined. NAFLD has been verified in all patients for the first time. The clinical manifestations of NAFLD have been studied in comparative terms. The state of lipid and carbohydrate metabolism, insulin resistance have been investigated. Results. Dyslipidemia at NAFLD is characterized by the increase in triglyceride levels over 1.7 mmol/l and hypoalphaholesterolemia whereby the level of HDL-C in men is less 1.0 mmol/l and is less 1.2 mmol/l in women. So that is the diagnostic criterion for NAFLD. These abnormalities were more pronounced in men, indicating to more severe lipid metabolism disorders in men. The immunoreactive insulin concentration was significantly higher in men, indicating to the men hyperinsulinemia severity. Insulin resistance index HOMA-IR was also significantly higher. Higher hypertriglyceridemia and insulin resistance suggest that the combination of these disorders and their greater severity contribute to the formation of liver steatosis in men well before. These disorders dominated mostly in young people. Conclusion. NAFLD in examined patients is mainly formed in middle age. This is facilitated by the emergence of significant disturbances in carbohydrate and lipid metabolism. The main pathophysiological factors contributing to the formation of NAFLD, namely, IR and dyslipidemia were more significant in men. Probably this may be due to earlier development of hepatic steatosis in men and younger age compared to women.
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References
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About Authors (Correspondence):
Kuimov A.D. – doctor of medical sciences, professor, head of the department of faculty therapy, honored physician of RF, honored scientist of RF, e-mail: terapia@mail.ru Krivosheev A.B. doctor of medical sciences, professor of the department of faculty therapy, e-mail: krivosheev-ab@narod.ru
Krivosheev A.B. – doctor of medical sciences, professor of the department of faculty therapy, e-mail: krivosheev-ab@narod.ru
Popov K.V. – professor of the department of faculty therapy, e-mail: kpopov54@mail.ru
Lozhkina N.G. – associate professor of faculty therapy, e-mail: terapia@mail.ru
Bogoryanova P.A. – assistant professor of faculty therapy, e-mail: terapia@mail.ru
Kondratova M.A. – student of faculty therapy, e-mail: terapia@mail.ru
Gubanova S.K. – clinical intern of the department of emergency treatment with endocrinology and pathology, e-mail: sofocka-mofocka@mail.ru
