№ 2 / 2017 / 5-11

Mechanism of pathological effect of multilayer carbon nanotubes with different levels of metallic impurities

Author: Vitkina T.I.¹, Yan’kova V.I.², Gvozdenko T.A.³, Kuznetsov V.L.⁴, Krasnikov D.V.⁵, Sidletskaya K.A.⁶, Chayka V.V.⁷, Golokhvast K.S.⁸

Author Affiliations

Abstract

The aim of the study was to research the mechanism of pathological effect of multi-walled carbon nanotubes (MWCNTs) with different content of metallic impurities. Material and methods: we evaluated the impact of two types of MWCNTs on peroxidation processes and state of immune cells in healthy donors in vitro. Results and discussion. We showed that the main mechanism of MWCNTs effect is oxidative stress, its intensity depends on the content of metal impurities. It is assumed that the effect of MWCNTs may cause switching to the classical way of IL-6 signaling for the regulation of the inflammatory process and compensation of apoptotic changes.

Key words

multi-walled carbon nanotubes, the mechanism of pathological effect

References

Volchegorskiy I.A., Nalimov A.G., Yarovinskiy B.G. et al. Comparison of various approaches to definition of products the POL in the heptane-izopropanol blood extracts // Voprosy meditsinskoy khimii = Problems of medical chemistry. 1989. (1). 127-131. [In Russian]
Galaktionova L.P., Molchanov A.V., Yel´chaninova S.A. et al. Status of peroxidation in patients with gastric and duodenal ulcer // Klinicheskaya laboratornaya diagnostika = Clinical laboratory diagnostics. 1998. 6. 10-14. [In Russian]
Yan´kova, V.I., Veremchuk L.V., Vitkina T.I. et al. Response the POL-AOS system on complex effect of factors of natural-ecological environment in respiratory diseases // Sibirskiy nauchnyy medtsinskiy zhurnal = Siberian Scientific Medical Journal. 2016. 36. (3). 94-102. [In Russian]
Dienz O., Rincon M. The effects of IL-6 on CD4 T cell responses // Clin. Immunol. 2009. 130. 27-33.
Dong J., Ma Q. Advances in mechanisms and signaling pathways of carbon nanotube toxicity // Nanotoxicology. 2015. 9. 658-676.
Elshal M.F., Salam M.A., Khan J.A. In vitro cytotoxicity and induction of apoptosis by multiwalled carbon nanotubes in human peripheral lymphocytes: correlation with physicochemical properties // Afr. J. Biotech. 2012. 11. (52). 11455-11462.
Fenoglio I., Tomatis M., Lison D. et al. Reactivity of carbon nanotubes: free radical generation or scavenging activity? // Free Radic. Biol. Med. 2006. 40. 1227-1233.
Golokhvast K.S., Kuznetsov V.L., Chaika V.V. et al. Experimental simulation of man-made disasters when multi-walled carbon nanotubes get into liquid mediums // Pharma Chem. 2015. 7. (2). 132-137.
Golokhvast K., Vitkina T., Gvozdenko T. et al. Impact of atmospheric microparticles on the development of oxidative stress in healthy city/industrial seaport residents // Oxid. Med. Cell. Longev. 2015. 2015. 412173.
Gomes E.C., Florida-James G. Lung inflammation, oxidative stress and air pollution // Lung Inflammation / Ed. K.C. Ong. InTech, 2014. 978-953.
Jiang Y., Zhang H., Wang Y. et al. Modulation of apoptotic pathways of macrophages by surface-functionalized multi-walled carbon nanotubes // PLoS One. 2013. 8. e65756.
Kagan V.E., Tyurina Y.Y., Tyurin V.A. et al. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron // Toxicol. Lett. 2006. 165. 88-100.
Kuznetsov V.L., Krasnikov D.V., Schmakov A.N. et al. In situ and ex situ time resolved study of multi-component Fe-Co oxide catalyst activation during MWNT synthesis // Phys. Status Solidi. B. Basic Solid State Phys. 2012. 249. 2390-2394.
Kuznetsov V.L., Elumeeva K.V., Ishchenko A.V. et al. Multi-walled carbon nanotubes with ppm level of impurities // Phys. Status Solidi B. Basic Solid State Phys. 2010. 247. 2695-2699.
Lim S.S., Vos T., Flaxman A.D. et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 // Lancet. 2012. 380. 2224-2260.
Luo Y.H., Chang L.W., Lin P. Metal-based nanoparticles and the immune system: activation, inflammation, and potential applications // Biomed. Res. Int. 2015. 2015. 143720.
Manna S.K., Sarkar S., Barr J. et al. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-κB in human keratinocytes // Nano Lett. 2005. 5. (9). 1676-1684.
Moller P., Christophersen D.V., Jensen D.M. et al. Role of oxidative stress in carbon nanotube-generated health effects // Arch. Toxicol. 2014. 88. 1939-1964.
Nel A., Xia T., Madler L. et al. Toxic potential of materials at the nanolevel // Science. 2006. 311. 622-627.
Occupational Exposure to Carbon Nanotubes and Nanofibers // NIOSH Curr. Intell. Bull. 2013. (65). 156 p.
Paulsen M., Janssen O. Pro- and anti-apoptotic CD95 signaling in T cells // Cell Commun. Signal. 2011. 9. (7). ID PMC3090738.
Peng B., Locascio M., Zapol P. et al. Measurements of near-ultimate strength for multiwalled carbon nanotubes and irradiation-induced crosslinking improvements // Nat. Nanotechnol. 2008. 3. (10). 626-631.
Poland C.A., Duffin R., Kinloch I. et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study // Nat. Nanotechnol. 2008. 3. 423-428.
Rodriguez-Yanez Y., Munoz B., Albores A. Mechanisms of toxicity by carbon nanotubes // Toxicol. Mech. Methods. 2013. 23. 178-195.
Rossignol D.A., Frye R.E. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism // Front. Physiol. 2014. 5. 150.
Rydman E.M., Ilves M., Koivisto A.J. et al. Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation // Part Fibre Toxicol. 2014. 11. 48.
Shvedova A.A., Kisin E.R., Mercer R. et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice // Am. J. Physiol. Lung Cell. Mol. Physiol. 2005. 289. L698-L708.
Snyder-Talkington B.N., Dong C., Sargent L.M. et al. mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice // J. Appl. Toxicol. 2015. 328. 66-74.
Veremchuk L.V., Yan'kova V.I., Vitkina T.I. et al. Urban air pollution, climate and its impact on asthma morbidity // Asian Pac. J. Trop. Biomed. 2016. 6. (1). 76–79.

About Authors (Correspondence):

Vitkina T.I. – doctor of biological sciences, head of the laboratory of medical ecology and recreational resources, professor RAS, e-mail: tash30@mail.ru

Yan’kova V.I. – candidate of biological sciences, associate professor, senior researcher оf the laboratory of medical ecology and recreational resources, e-mail: jankova_nch@list.ru

Gvozdenko T.A. – doctor of medical sciences, chief researcher of the laboratory of rehabilitation treatment, e-mail: tagvozdenko@mail.ru

Kuznetsov V.L. – candidate of chemical sciences, senior researcher, head of group of the synthesis of surface areas compounds, e-mail: kuznet@catalysis.ru

Krasnikov D.V. – candidate of chemical sciences, researcher of group for the synthesis of surface areas compounds, e-mail: krasnikovdmitry@gmail.com

Sidletskaya K.A. – assistant-researcher of the laboratory for biomedical research, d-karolina-a@mail.ru

Chayka V.V. – candidate of biological sciences, senior researcher of Nanotechnology Research and Education Center, e-mail: chayka.vvdvfu@mail.ru

Golokhvast K.S. – doctor of biological sciences, senior researcher оf the laboratory of medical ecology and recreational resources, deputy director on development, e-mail: droopy@mail.ru

Received: 25/04/2017