Influence of glyprolines PGP, RGP, PRPGP on DNA synthesis in the epithelium of tongue and duodenum of white mice under physiological conditions and on a model of gastroenteropathy
Author Affiliations1The Far-East State Medical University of Minzdrav of Russia, 680000, Khabarovsk, Muraviev-Amurskiy str., 35
2The Far-East State Medical University of Minzdrav of Russia, 680000, Khabarovsk, Muraviev-Amurskiy str., 35
Abstract
The purpose of study. Influence of glyprolines PGP, RGP, PRPGP on the DNA synthesis in the epithelium of the tongue and duodenum of white mice under physiological conditions and on the model indometacin gastropathy was studied. Material and methods. Male white mice were used in the experiment. Peptides were administered intraperitoneally at a dose of 1 mg / kg, indomethacin – 250 mg / kg. Proliferative activity was evaluated with 3Н-thymidine autoradiography (dosage 1 µgKu/g). We counted labeling nuclei index (LNI). Results and discussion. The fivefold peptides PGP, RGP, PRPGP introduction caused suppression of DNA synthesis in the surface epithelium of the tongue in physiological conditions. Peptide PRPGP reduces labeling nuclei index in the epithelium of duodenal. Intragastric administration of indomethacin caused the decrease in the proliferative activity of the surface epithelium of tongue and duodenum. Preliminary five times intraperitoneal injection of peptides PGP, RGP and PRPGP stimulates proliferative processes in the models of NSAID-gastropathy in the epithelium of the tongue and duodenum.
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References
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About Authors (Correspondence):
Fleyshman M.Yu. – doctor of medical sciences, assistant professor of the central scientific research laboratory, e-mail: marfl@yandex.ru
Tolstenok I.V. – applicant of the central scientific research laboratory, e-mail: toiv@bk.ru
