Investigation of the pharmacokinetic parameters of poloxamer-modified hyaluronidase during different routes of administration
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
5Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
Abstract
In experimental work on rats main pharmacokinetic parameters of poloxamer-modified hyaluronidase (PMH) were investigated during intragastric and intravenouse routes of administration. Intravenous injection has been found to be ineffective, since PMH weakly penetrates into tissues and is rapidly excreted. PMH enteral administration is followed by the absolute bioavailability of 23.97 %, the circulation time in blood plasma of 6 hours, the maximum concentration of 55.99 μg/ml, which is reached after 2 hours; the highest PMH level was found in the liver and kidneys. It is concluded that, from the point of view of clinical PGM positioning, the enteral route of delivery is optimal.
Key words
References
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About Authors (Correspondence):
Shilova M.A. – postgraduate student of the chair for pharmacology, clinical pharmacology and evidentiary medicine, e-mail: pharmacevt85@list.ru
Yershov K.I. – candidate of medical sciences, assistant of the chair for pharmacology, clinical pharmacology and evidentiary medicine
Grek O.R. – doctor of medical sciences, professor of the chair for pharmacology, clinical pharmacology and evidentiary medicine
Madonov P.G. – doctor of medical sciences, professor, head of the chair for pharmacology, clinical pharmacology and evidentiary medicine
Fil’ M.E. – 4th year student of the medical faculty
