Differences in the changes of pulmonary ventilation and gas exchange during low-level respiratory resistive loading in healthy subjects and copd patients
Author Affiliations1Research Institute of Physiology and Basic Medicine, 630117, Novosibirsk, Timakov str., 4; Novosibirsk State University, 630090, Novosibirsk, Pirogov str., 2
2Research Institute of Physiology and Basic Medicine, 630117, Novosibirsk, Timakova str., 4
3Scientific Research Institute of Physiology and Basic Medicine, 630060, Novosibirsk, Timakov str., 4
4Scientific Research Institute of Physiology and Basic Medicine, 630060, Novosibirsk, Timakov str., 4
Abstract
The aim of the study was to evaluate differences in the changes of pulmonary ventilation and gas exchange during low-level respiratory resistive loading (RRL) in health and COPD. The study involved 14 healthy volunteers and 11 COPD patients. Pulmonary gas exchange was measured for 7 minutes without respiratory resistive load and 7 minutes with RRL 0.4 cm H2O·l-1·s. Decrease in oxygen consumption and carbon dioxide production during RRL was significantly greater in COPD patients than in healthy subjects (14 vs. 8 %, p < 0.009 and 16 vs. 10 %, p < 0.020 respectively). Tidal volume increased by 13 % in healthy subjects only. The differences in pulmonary gas exchange shifts during RRL can be used to improve early COPD diagnosis.
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About Authors (Correspondence):
Grishin O.V. – doctor of medical sciences, chief researcher of laboratory of functional reserves, e-mail: ovgrishin@physiol.ru
Uryumtsev D.Yu. – candidate of medical sciences, researcher of laboratory of functional reserves, e-mail: piud@physiol.ru
Gul’tyaeva V.V. – candidate of biological sciences, senior researcher of laboratory of functional reserves, e-mail: gultyaevavv@physiol.ru
Zinchenko M.I. – candidate of medical sciences, researcher of laboratory of functional reserves, e-mail: miz@physiol.ru
