The Siberian Scientific Medical Journal
№ 2 / 2017 / 82-87

Biomarkers of early damage of kidneys in arterial hypertension

Author Affiliations


Arterial hypertension is in itself an important risk factor for cardiovascular disease, and together with kidney disease, this risk increases many times over. The modern ideas of a hypertensive nephropathy, its pathogenesis are presented in the literary review. Classic biomarkers of disease and the results of researches describing the new early biomarkers of kidney injury (neutrophil gelatinase-associated lipocalin, NGAL, kidney injury molecule-1, KIM-1, symmetric dimethylarginine, prorenin, uromoduline, retinol-binding protein, transforming growth factor- β, plasminogen activator inhibitor-1) are given in the review.

Key words

arterial hypertension, glomerulosclerosis, tubulointerstitial fibrosis plasminogen activator inhibitor-1, uromoduline, neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding prprorenin, the plasminogen activator inhibitor 1, transforming growth factor-β, prorenin, symmetric dimethylarginine, kidney injury molecule-1 (KIM-1)
About Authors (Correspondence):

Khudyakova A.D. – fellow physician, e-mail:

Ragino Yu.I. – doctor of medical sciences, professor, corresponding member of RAS, deputy director on scientific researches, head of laboratory of clinical-population and preventive investigations of therapeutic and endocrine diseases, e-mail:

Received: 25/04/2017