Congenital immunity values in the inductive phase of immune response of patients with concomitant injury
The values of congenital immunity were investigated in the first day after severe concomitant injury in 10 patients with uncomplicated posttraumatic period, as well as in 9 patients with pneumonia developed within 3.0±1.0 days after injury. The inductive phase of immune response in patients with favorable course of posttraumatic period was characterized by moderate leukocytosis, moderate decrease in the number of СD3-СD16+СD56+, down-regulation of the molecules of Class II major histocompatibility complex on monocytes not lower than 55 %, activation of oxygen-dependent metabolism of neutrophil granulocytes, moderate increase in the number of neutrophil extracellular traps (NET), presented as both early and mature forms. In the group with pneumonia the marked decrease in HLADR expression on monocytes (below 50 %), marked increase in NET number with a significant superiority towards mature forms. Therefore, these values of congenital immunity can be used as additional prognostic criteria of infection complication development in patients with concomitant injuries in the coming day after injury.
About Authors (Correspondence):
Chepeleva M.V. – candidate of medical sciences, senior researcher of clinical laboratory of microbiology and immunology, e-mail: Vladi_2000@hotbox.ru
Lyulin S.V. – doctor of medical sciences, head of scientific and clinical laboratory of multiple, combined and combat trauma, e-mail: firstname.lastname@example.org
Kuznetsova E.I. – junior researcher of clinical laboratory of microbiology and immunology, e-mail: email@example.com
Sviridenko A.S. – junior researcher of scientific and clinical laboratory of multiple, combined and combat trauma, e-mail: firstname.lastname@example.org