The Siberian Scientific Medical Journal
№ 5 / 2014 / 79-83

The influence of the preoperative mri tumor characteristics on the efficiency of surgical treatment of glioblastoma patients

Author Affiliations


The aim of study was to determine the impact on the safety and radicality of resection of brain glioblastoma (GBM) such characteristics of the tumor determined by MRI as the proximity to the motor areas of the cerebral cortex, the depth, severity of perifocal edema, necrosis in the structure of the tumor. Material and methods: 80 patients with GBMs were operated in two independent neurosurgical centers. Patients of the first group (n = 40) were operated using combination of 5-ala microscopy and endoscopy. The second group patients (n = 40) underwent the conventional white light microsurgery. It has been revealed that tumor location in the non-dominant hemisphere far from the motor cortex, as well as moderate necrotic changes and perifocal edema are the MRI-determined predictors of maximum safe resection using both MRI neuronavigation and combined fluorescence navigation. However, the combined fluorescent navigation allows performing maximal safe resection of GBMs in case of intermediate tumor location and severe perifocal edema.

Key words

5-aminolevulinic acid, glioblastoma, magnetic resonance imaging, neuronavigation, fluorescent navigation
About Authors (Correspondence):

Gaytan A.S. - neurosurgeon, e-mail:
Krivoshapkin A.L. - doctor of medical sciences, professor, corresponding member of RAS, head of the centre of angioneurology and neurosurgery, e-mail:
Kanygin V.V. - candidate of medical sciences, associate professor of the chair for neurosurgery, e-mail:
Valentik A.V. - radiologist of department of X-ray computed tomography, e-mail:
Karaskov A.M. - doctor of medical sciences, professor, academician of RAS, director

Full Text

Received: 07/02/2015