The influence of the preoperative mri tumor characteristics on the efficiency of surgical treatment of glioblastoma patients
The aim of study was to determine the impact on the safety and radicality of resection of brain glioblastoma (GBM) such characteristics of the tumor determined by MRI as the proximity to the motor areas of the cerebral cortex, the depth, severity of perifocal edema, necrosis in the structure of the tumor. Material and methods: 80 patients with GBMs were operated in two independent neurosurgical centers. Patients of the first group (n = 40) were operated using combination of 5-ala microscopy and endoscopy. The second group patients (n = 40) underwent the conventional white light microsurgery. It has been revealed that tumor location in the non-dominant hemisphere far from the motor cortex, as well as moderate necrotic changes and perifocal edema are the MRI-determined predictors of maximum safe resection using both MRI neuronavigation and combined fluorescence navigation. However, the combined fluorescent navigation allows performing maximal safe resection of GBMs in case of intermediate tumor location and severe perifocal edema.
About Authors (Correspondence):
Gaytan A.S. - neurosurgeon, e-mail: email@example.com
Krivoshapkin A.L. - doctor of medical sciences, professor, corresponding member of RAS, head of the centre of angioneurology and neurosurgery, e-mail: firstname.lastname@example.org
Kanygin V.V. - candidate of medical sciences, associate professor of the chair for neurosurgery, e-mail: email@example.com
Valentik A.V. - radiologist of department of X-ray computed tomography, e-mail: firstname.lastname@example.org
Karaskov A.M. - doctor of medical sciences, professor, academician of RAS, director