EPIGENETICS AND METHODS OF ITS REALIZATION
Abstract
The most actual aspects of genetics associated with the epigenetic component of the regulation of gene expression are considered. Attention is paid to the development of ideas on epigenetics, as a separate field of knowledge on the functioning of genes, and an integral part of classical genetics. The concepts of epigene and epigenetic reprogramming are highlighted. The most known molecular mechanisms of epigenetic regulation of the gene function are considered. The importance of research in the field of epigenetics for the development of science and medicine was emphasized.
Key words
References1. Appel B., Muller S. Nucleic acids: from A to Z. Moscow, 2013. 413 p. [In Russian].
2. Delone N.L. Essays on problems of heredity in space biology. Moscow, 2013. 208 p. [In Russian].
3. Yezhova T.A., Wu H.C. Genetic and epigenetic regulation of leaf morphogenesis // Vestnik Tverskogo gosudarstvennogo universiteta. Seriya: Biologiya i ekologiya = Bulletin of Tver State University. Series: Biology and Ecology. 2008. (9). 66-75. [In Russian].
4. Zhimulev I.F. The mosaic effect of the position of the gene // Sorosovskiy obrazovatel'nyy zhurnal = Soros Educational Journal. 2001. 7. (1). 4-9. [In Russian].
5. Zakharov-Gezekhus I. A. Cytoplasmic heredity // Vavilovskiy zhurnal genetiki i selektsii = Vavilov journal of genetics and breeding. 2014. 18. (1). 93-102. [In Russian].
6. Inge-Vechtomov S.G, Borkhsenius A.S., Zadorskiy S.P. Protein heredity: conformational matrices and epigenetics // Vestnik Vavilovskogo obshchestva genetikov i selektsionerov = Bulletin of the Vavilov society of geneticists and breeders. 2004. 8. (2). 60-66. [In Russian].
7. Kovalenko T.F. Methylation of the genome of mammals // Molekulyarnaya meditsina = Molecular medicine. 2010. (6). 24–267. [In Russian].
8. Kurchanov V.V. Behavior: an evolutionary approach. Moscow, SpetsLit. 2011. 73 c. [In Russian].
9. Kushnirov V.V. Prion and non-prone amyloids: study in the yeast model: abstract of thesis…doctor of medical sciences. Moscow, 2008. [In Russian].
10. Lavrov S.A., Shatskirh A.S., Kibanov M.V., Gvozdev V.A. Correlation between cellular level of gene transcriptional silencing and heterochromatin compartment dragging in case of PEV-producing eu-heterochromatin rearrangement in Drosophila melanogaster // Mol. Biol. (Mosc.) 2013. 47. (2). 252–258.
11. Maletskiy S.I., Roik N.V., Dragavtsev V.A. The third variability, types of heredity and reproduction of seeds in plants // Sel’skokhozyaystvennaya biologiya = Agricultural Biology. 2013. (5). 3-29. [In Russian].
12. Mironova L.N. Protein heredity and regulation of gene expression in yeast // Ekologicheskaya genetika = Ecological genetics. 2010. 8. (4). 10-16. [In Russian].
13. Nazarenko S.A. Genomic imprinting and its role in the etiology of hereditary human diseases // Byulleten' sibirskoy meditsiny = Bulletin of Siberian medicine. 2004. (3). 8-17. [In Russian].
14. Patkin E.L., Quinn J. Genomic imprinting and its role in the etiology of hereditary human diseases // Ekologicheskaya genetika = Ecological genetics. 2010. 8. (4). 44-56. [In Russian].
15. Patkin E. L., Suchkova I.O. Regulatory mechanisms of imprinting in mammals // Tsitologiya = Cell and Tissue Biology. 2006. 48. (7). 578–594. [In Russian].
16. Ratner V.A., Vasil'eva L.A. Mobile genetic elements (MGE): "egoistic DNA" or functional part of the genome? // Modern concepts of evolutionary genetics: conf. mat. Novosibirsk, 2000. 145-170. [In Russian].
17. Ratner V.A. Genetics, molecular cybernetics: personalities and problems. Novosibirsk: Nauka, 2002. 106 s. [In Russian].
18. Rozanov V.A. Stress-induced epigenetic phenomena are another probable biological factor of suicide // Suitsidologiya = Suicidology. 2015. 6. (3). 3-19. [In Russian].
19. Salozhin S.V. Methylation of DNA – one of the major epigenetic markers // Biochemistry (Mosc.). 2005. 70. (5). 525–532.
20. Silicheva M.A. New aspects of position effect of Drosophila melanogaster transgenes: abstract of thesis…candidate of biological sciences. Moscow, 2008. [In Russian].
21. Fomchenko E.E., Voropaev E.V. Biological aspects of DNA methylation // Problemy zdorov'ya i ekologii = Health and Environment Issues. 2012. (3). 55-59. [In Russian].
22. Chekhun V. Epigenetics of Cancer // Onkologiya = Oncology. 2008. 10. (3). 301–312. [In Russian].
23. Shirin A.D., Kaletin G.I, Baranova O.Yu. Epigenetics in oncohematology: a brief abstract review // Klinicheskaya onkogematologiya = Clinical oncohematology. 2015. 8. (1). 26–30. [In Russian].
24. Barr M.L., Bertram E.G. A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis // Nature. 1949. 163. (4148). 676–677.
25. Bégin P., Nadeau K. C. Epigenetic regulation of asthma and allergic disease // Allergy Asthma Clin. Immunol. 2014. 10. (1). 27-28.
26. Benyajati C.W., Worcel A. Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster // Cell. 1976. 9. (3). 393-407.
27. Borunova V.A., Iarovaia O.V., Vassetzky Y.S., Razin S.V. The upstream area of the chicken α-globin gene domain is transcribed in both directions in the same cells // FEBS Lett. 2005. 579. (21). 4746-4750.
28. Castel S. E., Martienssen R. A. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond // Nat. Rev. Genet. 2013. 14. (2). 100–112.
29. Catherine H., Antoine B., Laure T. et al. Paramutation in drosophila requires both nuclear and cytoplasmic actors of the piRNA pathway and induces cis-spreading of piRNA Production // Genetics. 2015. 201. 1381–1396.
30. Hale C.J., Stonaker J.L., Gross S.M., Hollick J.B. A novel Snf2 protein maintains trans-generational regulatory states established by paramutation in maize // PLoS Biol. 2007. 5. (10). e275.
31. Dawson M. A., Kouzarides T. Cancer epigenetics: from mechanism to therapy // Cell. 2012. 150. (1). 12–27.
32. Fitch K.R., Wakimoto B.T. The paternal effect gene ms(3)sneaky is required for sperm activation and the initiation of embryogenesis in Drosophila melanogaster // Dev. Biol. 1998. 197. (2). 270–282.
33. Gavrilov A.A. Mapping of the nuclear matrix bound chromatin hubs by a new M3C experimental procedure // Nucleic Acids Res. 2010. 38. (22). 8051–8060.
34. Gavrilov A.A., Razin S.V., Spatial configuration of the chicken (alpha) globin gene domain: Immature and active chromatin hubs // Nucleic Acids Res. 2008. 36. 4629–4640.
35. Gavrilov A.A., Zukher I.S., Philonenko E.S. et al. Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure // Nucleic Acids Res. 2010. 38. 8051–8060.
36. Gurvich N., Berman M.G., Wittner B.S. et al. Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo // FASEB J. 2004. 19. (9). 1166–1168.
37. Harring M., Bader R., Louwers M. et al. The role of DNA methylation, nucleosome occupancy and histone modifications in paramutation // Plant J. 2010. 63. (3). 366–378.
38. Hoki Y., Kimura N., Kanbayashi M. et al. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse // Development. 2009. 136. 139–146.
39. Herzing L.B., Romer J.T., Horn J.M. et al. Xist has properties of the X-chromosome inactivation centre // Nature. 1997. 386. 272–275.
40. Jeffrey J.J., Chang H.Y. Unique features of long non-coding RNA biogenesis and function // Nat. Rev. Genet. 2015. 17. (1). 47–62.
41. Kaminskas E., Farrell A., Abraham S. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes // Clin Cancer Res. 2005. 11. (10). 3604–3608.
42. Kaneko-Ishino T., Ishino F. Retrotransposon silencing by DNA methylation contributed to the evolution of placentation and genomic imprinting in mammals // Development. 2010. 52. (6). 533–543.
43. Klochkov D., Rincón-Arano H., Ioudinkova E.S. et al. A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain // Mol. Cell. Biol. 2006. 26. 1589-1597.
44. Knoll J.H., Nicholls R.D., Magenis R.E. Angelman and Prader-Willi syndromes share a common chromosome deletion but differ in parental origin of the deletion // Am. J. Med. Genet. 1989. 32. (2). 285—290.
45. Laubach J. P., Moreau P., San-Miguel J.F. Panobinostat for the treatment of multiple myeloma // Clin. Cancer. Res. 2015. 21. (21). 4767–4773.
46. Law J.A., Jacobsen S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals // Nat. Rev. Genet. 2010. 11. (3). 204–220.
47. Lee T.I., Young R.A. Transcriptional regulation and its misregulation in disease // Cell. 2013. 152. (6). 1237–1251.
48. Lee J.T., Jaenisch R. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome // Nature. 1997. 386. 275–279.
49. Li W., Notani D., Rosenfeld M.G. Enhancers as non-coding RNA transcription units: recent insights and future perspectives // Nat. Rev. Genet. 2016. 17. (4). 207—223.
50. Mann J.R. Imprinting in the germ line // Stem Cells. 2001. 19. (4). 287–294.
51. Martínez J.A., Milagro F.I., Claycombe K.J., Schalinske K.L. Epigenetics in adipose tissue, obesity, weight loss, and diabetes // Adv. Nutr. 2014. 5. (1). 71–81.
52. Mehler M.F. Epigenetic principles and mechanisms underlying nervous system functions in health and disease // Progr. Neurobiol. 2008. 86. 305–341.
53. Merry C.R., Forrest M.E., Sabers J.N. et el. DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer // Hum. Mol. Genet. 2015. 24. (21). 231-233.
54. Rassoulzadegan M., Grandjean V., Gounon P. et al. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse // Nature. 2006. 441. 469-474.
55. Rassoulzadegan M., Cuzin F. From paramutation to human disease: RNA-mediated heredity // Semin. Cell Dev. Biol. 2015. 44. 47–50.
56. Ng K., Pullirsch D., Leeb M., Wutz A. Xist and the order of silencing // EMBO Rep. 2007. 8. 34–29.
57. Ohno S., Kaplan W.D., Kinosita R. Formation of the sex chromatin by a single X-chromosome in liver cells of rattus norvegicus // Exp. Cell Res. 1959. 18. 415–419.
5. Petrova N.V., Iarovaia O.V., Verbovoy V.A. Specific radial positions of centromeres of human chromosomes X, 1, and 19 remain unchanged in chromatin-depleted nuclei of primary human fibroblasts: evidence for the organizing role of the nuclear matrix // J. Cell. Biochem. 2005. 96. 850-857.
59. Razin S.V., Rynditch A., Borunova V. et al. The 33 kb transcript of the chicken a-globin gene domain is part of the nuclear matrix // J. Cell Bioch. 2004. 92. 445-457.
60. Reik W. Genomic imprinting and genetic disorders in man // Trends Genet. 1989. 5. (10). 331-336.
61. Tanaka K., Matsumoto K., Toh-e A. Dual regulation of the expression of the gene by cyclic AMP and heat shock in yeast // EMBO J. 1988. 7. (2). 495-502.
62. Tang W.Y., Ho S.M. Epigenetic reprogramming and imprinting in origins of disease // Rev. Endocr. Metab. Disord. 2007. 8. 173–182.
63. True H.L., Berlin I., Lindquist S.L. Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits // Nature. 2004. 431. 184–187.
64. True H.L., Lindquist S.L. A yeast prion provides a mechanism for genetic variation and phenotypic diversity // Nature. 2000. 407. 477–483.
65. Valadez-Graham V., Razin S.V., Recillas-Targa F. CTCF-dependent enhancer blockers at the upstream region of the chicken a-globin gene domain // Nucleic Acids Res. 2004. 32. 1354-1362.
66. Li W., Notani D., Rosenfeld M.G. Enhancers as non-coding RNA transcription units: recent insights and future perspectives // Nat. Rev. Genet. 2016. 17. 207–223.
67. Wilkins M. Proteomics data mining // Expert Rev. Proteomics. 2009. 6. (6). 599–603.
68 Wilkinson M., Lawrence S., William D. et el. Genomic imprinting effects on brain development and function // Nat. Rev. Neurosci. 2007. 8. (11). 832–843.
69. Fu Y., Lee I., Lee Y.S., Bao X. Small non-coding transfer RNA-derived RNA fragments (tRFs): their biogenesis, function and implication in human diseases // Genomics Inform. 2015. 13. (4). 94-101.
Veselov A.A. – candidate of medical sciences, associate professor of the chair of eye diseases, e-mail: Magicjack@mail.ru
