ASSOCIATION OF SURFACTANT PROTEIN A BLOOD LEVEL WITH THE CLINICAL CHARACTERISTICS OF PNEUMONIA
Aim of the study – to investigate the association of blood surfactant protein A level with the clinical characteristics of pneumonia. Material and methods. The main group consisted of 72 patients with pneumonia; the average age was 56.3 ± 1.9 years, body mass index of 25.7 ± 1.2 kg/m2. The comparison group consisted of 26 patients without pneumonia, with an average age of 53.0 ± 3.8 years, body mass index of 25.9 ± 1.1 kg/m2. All patients underwent clinical, functional-diagnostic and laboratory tests. The blood serum surfactant protein A level was measured by enzyme immunoassay. Results. The patients with pneumonia had increased mean values of body temperature, 1.1-fold enhanced heart rate, 1.2-fold increased frequency of respiratory movements in comparison with the second group of patients. Shortness of breath was 1.3 times more frequent, cough – 2.6 times more often, sputum – 5 times more often in patients with pneumonia. Saturation of blood oxygen according to pulse oximetry in patients with pneumonia was lower than in the comparison group. The blood concentration of surfactant protein A was 1.5 times higher in patients with pneumonia than in the comparison group. Conducted correlation analysis revealed the association of blood levels of surfactant protein and some clinical characteristics of the patients with pneumonia. Conclusion. Elevated blood levels of surfactant protein A in pneumonia may be an important new biomarker for this disease.
About Authors (Correspondence):
Ragino Yu.I. – doctor of medical sciences, corresponding member of RAS, deputy director on scientific work, head of laboratory for clinical and hormonal researches, e-mail: firstname.lastname@example.org