The Siberian Scientific Medical Journal
 
 
№ 5 / 2017 / 49-54

INFLUENCE OF OPTICAL NEURITIS ON NEURO DEGENERATIVE PROCESS IN RETINA GANGLIA CELLS COMPLEX IN PATIENTS WITH RECIDIVATING DISSEMINATED SCLEROSIS

Author Affiliations

Abstract

Aim of the research: to determine the role of underwent optical neuritis in the intensity of changes of optical coherent tomography data of retina in patients with multiple sclerosis. Material and methods. The analysis of 73 clinical observations of patients with evidential remittent and secondary progressive with aggravations multiple sclerosis has been carried out according to McDonald 2010 criteria (145 eyes altogether, 130 eyes after illumination of contralateral eyes in the group of patients underwent optical neuritis). Results and discussion. The obtained data demonstrate that the underwent optical neuritis in patients with multiple sclerosis (in the disease debut or as one of following aggravations) shows pronounced influence on neurodegenerative process development in retina ganglion cell layer complex. The marked decrease both in average macula retinal thickness parameters and retinal neuronal fiber layer as well as ganglion cell layer indexes has been determined in group of patients underwent optical neuritis.

Key words

multiple sclerosis, optic neuritis, optical coherent tomography of retina, neurodegeneration, peripapillary fibers, ganglion cell layer
References
About Authors (Correspondence):

Sazonov D.V. – head of department of clinical trials, neurologist, e-mail: d.sazonov_ocrs@mail.ru

Full Text

Received: 29/10/2017
Accepted: 29/10/2017