INTERACTION BETWEEN MAIN FACTORS OF METABOLIC SYNDROME PATHOGENESIS AND ITS COMPONENTS IN MEN
Objective: to study the dependence of the parameters characterizing the metabolic syndrome (MS) and its components on the availability and various combinations of the main factors of its pathogenesis in men. Material and methods. A survey of 239 men working at an industrial enterprise was carried out. The criteria of the Consensus of international experts in the fields of cardiology and endocrinology (2009) were used to verify the MS and its main components; the index of insulin resistance HOMA-IR was calculated; the dysfunction of visceral adipose tissue was determined by calculating the index of visceral obesity; testosterone deficiency was detected at testosterone blood levels no more than 12 nmol/L. Results and discussion. The frequency of occurrence and expression degree of the parameters characterizing the MS and its components are directly proportional to the number of its pathogenesis factors simultaneously detected in the men surveyed. Thereat the pathogenetic role of testosterone deficiency was manifested only in the late stages of MS development when connected to the combination of insulin resistance with dysfunction of visceral adipose tissue.
About Authors (Correspondence):
Lutov Yu.V. – candidate of medical sciences, senior researcher of the laboratory of endocrinology, e-mail: firstname.lastname@example.org