INFLUENCE OF PRIMARY POSTERIOR CAPSULOREXIS ON THE ACTIVITY OF LOCAL INFLAMMATORY PROCESS AT FACOEMULSIFICATION OF COMPLICATED CATARACT ON THE BACKGROUND OF THE PSEUDOEXPHOLIATION SYNDROME

Author: Egorova E.V.¹, Obukhovа O.O.², Gorbenko O.M.³, Shvayuk A.P.⁴, Chernykh V.V.⁵, Trunov A.N.⁶

Abstract

Purpose: to study the activity of the local inflammatory process in patients with complicated cataracts with pseudoexfoliation syndrome before and after phacoemulsification with the primary posterior capsulorhexis. 54 patients (54 eyes) aged 50 to 92 years (76 ± 7.43) appealed for surgical treatment of complicated cataracts with pseudoexfoliation syndrome were examined. The concentration of IL-6, IL-10, MMP-9, TGF-β1 was determined in the tear fluid of patients before and on the 5th day of the postoperative period. It was established that the activity of local inflammatory process (high concentrations of IL-6 and MMP-9) is determined in patients with complicated cataracts with pseudoexfoliation syndrome. The identified increase in TGF-1 concentrations is a significant factor in the formation of the pseudoexfoliation material. It has been established that the use of a modified surgical technique in patients with pseudoexfoliation syndrome does not lead to activation of the local inflammation process

Key words

inflammation, posterior capsulorhexis, complicated cataract, pseudoexfoliation syndrome, cytokines

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About Authors (Correspondence):

Trunov A.N. – doctor of medical sciences, professor, deputy director for science work, head of the laboratory of immunology, e-mail: trunov1963@yandex. ru

Full Text

snmzh_1-2018_egorova_i_dr.pdf

Received: 26/02/2018

Accepted: 26/02/2018