The Siberian Scientific Medical Journal
№ 3 / 2018 / 49-53
DOI 10.15372/SSMJ20180307


Author Affiliations


The aim of the research was to study the effectiveness of bullous keratopаthy surgical treatment by modified method of operative intervention including intra-chamber injection of autologous blood mononuclear cells suspension with subsequent layering on the inner surface of the cornea. Material and methods. Clinical studies were conducted among 44 patients who comprised two groups: the main group (21 patients) and comparison group (23 patients). The treatment of the main group was carried out by a new method. The treatment of the comparison group was traditional pharmacotherapy. Results and discussion. The cornea hydration reduction in the main group was noted during the first 5 days after surgical treatment. The moderate decrease of corneal oedema in the comparison group started on 10–12 days. The pachymetry index decreased by 11 % in the main group and by 3.1 % in the comparison group after 1 month of treatment. Visual acuity increased fivefold in the main group and twofold in the comparison group. Conclusion. The use of the modified surgical treatment of the bullous keratopаthy promotes a faster decrease in the cornea hydration and stable improvement in visual acuity in the postoperative period compared with the course of conservative treatment.

Key words

bullous keratopаthy, autologous blood mononuclear cells, cytokines, endothelium, proliferation
About Authors (Correspondence):

Filippova E.O. – candidate of technical sciences, assistant of the department of ophthalmology, e-mail:

Full Text

Received: 28/06/2018
Accepted: 28/06/2018