Transport forms of steroid hormones in the blood, their connection with the development of some physiological and pathological processes

It is shown that blood lipoproteins transferred at least 40% of steroid hormones, including cortisol, corticoste-rone, testosterone, progesterone. Constant of binding for these hormones is ~ 10⁶ М^-1. In the high density lipo-protein the protein binding steroid hormones is apolipoprotein A-I. This form of transport has high biological activity as a transcription factor. It enhances gene expression and the rate of protein biosynthesis in liver cells. Free form of hormones can not penetrate cell membranes due to the formation of hydrogen bonds of CO and OH groups of hormones with OH and NH groups of both proteins and lipids. The hydrophobic interactions of hormones with the lipid phase of membranes is also hampering in this penetration.

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Panin L.E. – doctor of medical sciences, professor, academician of RAMS, director, e-mail: ibch@soramn.ru