Oxidative stress as nonspecific pathogenetic link of reproductive disorders (systematic review)

The analysis of national and foreign literature for the last few years as well as the results obtained by the Scientific Centre for Problems of Family Health and Human Reproduction SВ RAMS clearly indicate that oxidative stress accompanies and / or is a key pathogenetic link in the development of many types of reproductive disorders. On the basis of this fact it seems appropriate that further researches of the roles of the “lipid peroxidation – antioxidant protection” system are essential. Moreover, there is a good reason for antioxidants complex administration with regard to the oxidative imbalance nature.

1.   Kulakov V.I., Lopatina T.V. Reproductive health of the population of Russia // Infertile marriages. Current approaches to diagnosis and treatment / Ed. V.I. Ku^­lakov. M., 2006. 10–19. (in Russian)

2.   Kolesnikova L.I., Suturina L.V., Labygina A.V. et al. Violations of reproductive health and reproductive capacity in the present conditions in Eastern Siberia // Byul. VSNC SO RAMN. 2007. (2). 41–44. (in Russian)

3.   Filippov O.S. Infertile marriage in Western Siberia: abstract of thesis … doctor of medical sciences. M., 1999. (in Russian)

4.   Adamyan L.V., Kalinina E.A., Kolotovkina A.V. et al. Clinical and embryological aspects of endometriosis-associated infertility (literature review) // Problemy reproduktsii. 2010. 16. (5). 47–51. (in Russian)

5.   Infertile marriage / Ed. V.I. Kulakov. M.: GEOTAR-Media, 2005. 616 p. (in Russian)

6.   Kuzmenko E.T. Clinical and epidemiological aspects of female infertility (by the example of the Irkutsk region): abstract of thesis … kandidate of medical sciences. Irkutsk, 2008. (in Russian)

7.   Zenkov N.K., Lankin V.Z., Menshchikova E.B. Oxidative stress: Biochemical and pathophysiological aspects. M.: MAIK «Nauka/Interperiodica», 2001. 343 p. (in Russian)

8.   Velichkovsky B.T. Free radical oxidation as a link of early and prolonged adaptation to environmental factors // Byul. RAMN. 2001. (6). 45–52. (in Russian)

9.   Vladimirov Yu.A. Free radicals and antioxidants // Byul. RAMN. 1998. (7). 43–51. (in Russian)

10. Kryzhanovsky G.N. Dysregulyation pathology. M.: Meditsina, 2002. 630 p. (in Russian)

11. Sazontova T.G., Archipenko Y.V. Value of the balance of prooxidants and antioxidants – equivalent participants of metabolism // Patologich. fiziol. eksperim. terapiya. 2007. (3). 2–18. (in Russian)

12. Menshchikova E.B., Zenkov N.K., Lankin V.Z. et al. Oxidative stress: pathological conditions and diseases. Novosibirsk: ARTA, 2008. 284 p. (in Russian)

13. Kolesnikov S.I., Kolesnikova L.I., Dolgikh V.V. et al. Brain functional activity and lipids peroxidation processes in children at psychosomatic pathology formation. Novosibirsk: Nauka, 2008. 200 p. (in Russian)

14. Osipova E.V., Kolesnikova L.I., Malyshev V.V. Bioelements and hemispheric asymmetry at diseases of the nervous system in children. Novosibirsk: Nauka, 2006. 188 p. (in Russian)

15. Ruder E.H., Hartman T.J., Goldman M.B. Impact of oxidative stress on female fertility // Curr. Opin. Obstet. Gynecol. 2009. 21. (3). 219–222.

16. Zenkov N.K., Kandalintseva N.V., Lankin V.Z. et al. Phenolic antioxidants. Novosibirsk, 2003. 328 p. (in Russian)

17. Kolesnikova L.I., Osipova E.V., Grebenkina L.A. Oxidative stress in the reproductive endocrine genesis disorders of women. Novosibirsk: Nauka, 2011. 137 p. (in Russian)

18. Suturina L.V., Kolesnikova L.I. The main patho­genetic mechanisms and methods of correction of reproductive disorders in patients with hypothalamic syndrome. Novosibirsk: Nauka, 2001. 134 p. (in Russian)

19. Agarwal А., Alamaneni S. Oxidants and antioxidants in human fertility // Middle East. Fertility J. 2004. 9. 187–197.

20. Kolesnikova L.I., Zagarskih E., Kolesnikov S.I. et al. Medico-social aspects of the formation of violations of reproductive capacity among adolescent boys, living in industrial centers. Novosibirsk: Nauka, 2010. 100 p. (in Russian)

21. Makker K., Agarwal A., Sharma R. Oxidative stress and male infertility // Indian J. Med. Res. 2009. 129. (4). 357–367.

22. Agarwal А., Gupta S., Sekhon L. et al. Redox considerations in reproductive function and assisted reproduction: from molecular mechanisms to health implications // Antioxid. Redox Signal. 2008. 10. (8). 1375–1403.

23. Protopopova N.V., Kolesnikova L.I., Il’in V.P. Metabolism and hemodynamics in pregnant women with hypertension. Novosibirsk: Nauka, 2000. 260 p. (in Russian)

24. Protopopova N.V., Kravchuk N.V., Kolesniko­va L. I. Pathogenetic mechanisms of intrauterine growth retardation. Novosibirsk: Nauka, 2002. 196 p. (in Russian)

25. Sklyar N.V. Main mechanisms of estrogen metabolism disorders, lipid peroxidation processes, and antioxidant system in women with uterine myoma and infertility: abstract of thesis … candidate of medical sciences. Irkutsk, 2008. (in Russian)

26. Sholokhov L.F., Kolesnikova L.I., Protopopova N.V. et al. Patterns of adaptive and dysadaptive reactions of the neuroendocrine regulation of the organism in the course of pregnancy in women with varying degrees of risk of perinatal pathology // Zdorov’e. Meditsinskaya ekologiya. Nauka. 2009. 39–40. (4–5). 203–205. (in Russian)

27. Ter-Avanesov G.V. Correction of reproductive function of men with endocrine disorders. Practical guide. M., 2002. 63 p. (in Russian)

28. Safronenko A.V. Main changes of elemental and hormonal-metabolic status in men with pathospermia: abstract of thesis … candidate of medical sciences. Irkutsk, 2008. (in Russian)

29. Artymuk N.E. Leptin and reproductive system in women with hypothalamic syndrome // Akusherstvo i ginekologiya. 2003. (4). 36–39. (in Russian)

30. Arroyo A., Laughlin G.A., Morales A.J. et al. Inappropriate gonadotropin secretion in polycystic ovary syndrome – influence of adiposity // J. Clin. Endocrinol. Metab. 1997. 82. (11). 3728–3733.

31. Sukhinina K.V. Features of the body component composition and endocrine-metabolic status of systems for different variants of the hypothalamic syndrome course of puberty in girls: abstract of thesis … candidate of biological sciences. Irkutsk, 2007. (in Russian)

32. Danusevich I.N. Violation of ovarian function in women with hypothalamic syndrome (problems of pathogenesis and diagnosis): abstract of thesis … candidate of medical sciences. Irkutsk, 2000. (in Russian)

33. Darzhaev Z.Yu. Secondary polycystic ovaries in the form of neuroendocrine hypothalamic syndrome (problems of pathogenesis and diagnosis): abstract of thesis … candidate of medical sciences. Irkutsk, 2000. (in Russian)

34. Suturina L.V. Hypothalamic syndrome: basic patho­genesis, diagnosis, pathogenetic therapy and prog­nosis: abstract of thesis … doctor of medical sciences. Irkutsk, 2002. (in Russian)

35. Kurashova N.A. Changes in neurohormonal regulation and free radical oxidation of lipids in women with hypothalamic syndrome in different age periods: abstract of thesis … candidate of biological sciences. Irkutsk, 2005. (in Russian)

36. Dedov I.I., Kuraeva T.L., Peterkova V.A. et al. Diabetes mellitus in children and adolescents. A guide for doctors. M.: Universum Publishing, 2003. 391 p. (in Russian)

37. Jovanovic-Peterson L. Hormone replacement therapy and diabetes // Clin. Diabet. 1996. 142. 146–151.

38. Darenskaya M.A. Regularities of LPO – AOP and hormonal regulation in different periods of formation of the reproductive system in patients with type 1 diabetes mellitus: abstract of thesis … candidate of biological sciences. Irkutsk, 2005. (in Russian)

39. Murphy A.A. Clinical aspects of endometriosis // Ann. N. Y. Acad. Sci. 2002. 955. 1–10.

40. Augoulea A., Mastorakos G., Lambrinoudaki I. et al. The role of the oxidative stress in the endometriosis-related infertility // Gynecol. Endocrinol. 2009. 25. (2). 75–81.

41. Ermolova E.V. Diagnostic value of hormonal and metabolic abnormalities in infertility associated with endometriosis: abstract of thesis … candidate of medical sciences. Irkutsk, 2006. (in Russian)

42. Labygina A.V. The main clinical and pathogenetic variants of female endocrine sterility: abstract of thesis … doctor of medical sciences. Irkutsk, 2010. (in Russian)

43. Kornakova N.V. Functional status of the «lipid peroxidation – antioxidant protection» for women with endocrine sterility: abstract of thesis … candidate of biological sciences. Irkutsk, 2008. (in Russian)

44. Kolesnikova L.I. Role of lipid peroxidation in the pathogenesis of pregnancy complications: abstract of thesis … doctor of medical sciences. Irkutsk, 1993. (in Russian)

45. Galchenko E.V. The use of antioxidants in the treatment of women with ovarian dysfunction and dyshormonal mastopathy: abstract of thesis … candidate of medical sciences. Irkutsk, 2007. (in Russian)

46. Grebenkina L.A. Regularities in the formation of oxidative stress in women with diffuse mastopathy in the dynamics of the menstrual cycle: abstract of thesis … candidate of biological sciences. Irkutsk, 2007. (in Russian)

47. Abusueva Z.A., Korobeinikov A.P., Strizhova N.V. et al. Lipid peroxidation intensity at breast diseases and its status during hormone replacement therapy // Akusherstvo i ginekologiya. 2006. (1). 48–50. (in Russian)

48. Darenskaya M.A., Starostenko O.V. Ethnic peculiarities of lipid peroxidation and antioxidative defense in pregnant women in the presence of threatened abortion // Byul. VSNC SO RAMN. 2007. (1). 141–142. (in Russian)

49. Kolesnikova L.I., Darenskaya M.A., Grebenkina L.A. et al. The study of the status of lipid peroxidation in women of different ethnic groups with the threat of termination of pregnancy // Byul. VSNC SO RAMN. 2010. (6). 31–33. (in Russian)

50. Labygina A.V., Kolesnikova L.I., Suturina L.V. et al. Some clinical and metabolic characteristics of infertility in Russian and Buryat women // V International Congress on Reproductive Medicine. M., 2010. 105–106. (in Russian)

Vlasov B.Ya. – doctor of medical sciences, professor, senior researcher of the laboratory for reproduction phаtоphysiology, e-mail: iphr@sbamsr.irk.ru