Associations of the average corpuscular hemoglobin concentration in red cells with clinical characteristics of acute myocardial infarction
Author Affiliations1Regional Cardiologic Health Centre «Diagnostic and Cardio-vascular Surgery Center», 628400, Lenin avn., 69/1, Surgut, KMAO-Yugra
2Institute of Internal and Prevention Medicine of SB RAM, 630089, Novosibirsk, Boris Bogatkov str., 175/1, Novosibirsk State University, 630090, Novosibirsk, Pirogov str., 2
3Regional Cardiologic Health Centre «Diagnostic and Cardio-vascular Surgery Center», 628400, Lenin avn., 69/1, Surgut, KMAO-Yugra
4Regional Cardiologic Health Centre «Diagnostic and Cardio-vascular Surgery Center», 628400, Lenin avn., 69/1, Surgut, KMAO-Yugra
5Regional Cardiologic Health Centre «Diagnostic and Cardio-vascular Surgery Center», 628400, Lenin avn., 69/1, Surgut, KMAO-Yugra
6Regional Cardiologic Health Centre «Diagnostic and Cardio-vascular Surgery Center», 628400, Lenin avn., 69/1, Surgut, KMAO-Yugra
Abstract
The aim was to examine the association between the mean corpuscular haemoglobin concentration (MCHC) and clinical gender characteristics in acute myocardial infarction. Material and Methods: MCHC has been determined in 250 patients with acute myocardial infarction (AMI) with ST-segment elevation, mean age of 53.3 ± 8.9 years. The general blood test with MCHC determination was conducted with the hematology analyzer Sysmex xt-4000i. Results and Discussion: It was detected during the analysis of covariance that the most significant (p < 0.001) associations of MCHC were with hemoglobin (F = 4339), hematocrit (F = 3505), fatal events in combination with chronic anemia (F = 81.4), male gender in combination with cancer (F = 51.5), male gender (F = 40.4), cancer (F = 40.0), fatal events (F = 36.2) and chronic anemia (F = 18.9).
Key words
References1. Kishkun A.A. Guidance on laboratory methods for diagnosis. Moscow, 2007. 789 p. (in Russian)
2. Sokolova I.N. Changes in blood rheology in the application of thrombolytic therapy in patients with acute myocardial infarction: abstract of thesis…candidate of medical sciences. Moscow, 1994. (in Russian)
3. Akinbami A. Popoola A., Adediran A. et al. Full blood count pattern of pre-chemotherapy breast cancer patients in Lagos, Nigeria // Caspian J. Intern. Med. 2013.4. (1). 574–579.
4. Cecchi E., Liotta A.A., Gori A.M. et al. Comparison of hemorheological variables in ST-elevation myocardial infarction versus those in non-ST-elevationmyocardial infarction or unstable angina pectoris // Am. J. Cardiol. 2008. 102. (2). 125–128.
5. Cheng T.O. High hematocrit value is a risk factor for myocardial infarction // J. Thorac. Cardiovasc. Surg. 1999. 117. (1). 199–200.
6. Correia L.C. Souza A.C., Sabino M. el al. Hemoglobin level adds prognostic value to the global registry of acute coronary events score in non-ST elevation acute coronary syndromes // Cardiology. 2012. 121. (4). 213–219.
7. Fornal M., Wizner B., Cwynar M. et al. Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension // Clin. Hemorheol. Microcirc. 2013. [Epub ahead of print]. doi 10.3233/CH-131745.
8. Harrop R., Trasure P., de Belin J. et al. Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine MVA-5T4 (TroVax) // Cancer Immunol. Immunother. 2012. 61. (12). 2283–2294.
9. Inoue F., Hashimoto T., Tabuse H., Saito Y. Hematocrit as an indicator for coronary intervention in patients with acute myocardial infarction // J. Cardiol. 2003. 42. (6). 241–247.
10. Simbaqueba C., Shrestha K., Patarroyo M. et al. Prognostic implications of relative hypochromia in ambulatory patients with chronic systolic heart failure // Conquest. Heart Fail. 2013. 19. (4). 180–185.
11. Toss F., Nordström A., Nordström P. Association between hematocrit in late adolescence and subsequent myocardial infarction in Swedish men // Int. J. Cardiol. 2013. 168. (4). 3588–3593.
About Authors (Correspondence):
Urvantseva I.A. – candidate of medical sciences, head physician, e-mail: post@okd.ru
Nikolaev K.Yu. – doctor of medical sciences, professor, head of the laboratory of emergency treatment, e-mail: nikolaevky@yandex.ru
Salamatina L.V. – doctor of medical sciences, professor, e-mail: post@okd.ru
Milovanova E.V. – candidate of medical sciences, doctor-cardiologist, e-mail: post@okd.ru
Seitov A.A. – doctor-cardiologist, e-mail: post@okd.ru
Nikolaeva A.А. – doctor of medical sciences, professor, chief researcher, e-mail: nikolaev@sibmail.ru
Full Text