The Siberian Scientific Medical Journal
№ 5 / 2014 / 5-10

Ontogenetic and gender features of cytokine profile of rat lymph and blood serum

Author Affiliations


The investigation of lymph cellular composition and cytokine profile (IL-1α, IL-1β, IL -2, IL -4, IL -6, IL -10, GM-CSF, interferon-γ, TNFα,) of lymph, serum and conditioned medium of lymph cells of Wistar rats of 3 and 9 months age in norm have been carried out. The age and gender differences between the concentration of pro-and anti-inflammatory cytokines in the lymph and blood serum have been revealed. It was found that the concentrations of cytokines of investigated l Wistar rats` lymph were significantly higher compared to serum.

Key words

lymph, blood serum, cytokines
About Authors (Correspondence):

Poveshchenko A.F. – doctor of medical sciences, head of the laboratory, e-mail:

Orlov N.B. – candidate of medical sciences, leading researcher, e-mail:

Kazakov O.V. – candidate of biological science, leading researcher, e-mail:

Poveshchenko O.V. – candidate of medical sciences, head of the laboratory, e-mail:

Chepik V.I. – junior researcher

Kim I.I. – researcher, e-mail:

Bondarenko N.A. – postgraduate student, e-mail:

Miller T.V. – postgraduate student, e-mail:

Strunkin D.N. – candidate of medical sciences, researcher

Uzvarik L.M. – junior researcher, e-mail:

Kabakov A.V. – postgraduate student, e-mail:

Moskalchuk T.V. – postgraduate student, e-mail:

Konenkov V.I. – doctor of medical sciences, academician of RAS, director, e-mail:

Full Text

Received: 08/02/2015