№ 4 / 2014 / 11-17

Pathomorphological changes of the organs of pancreatoduodenal zone in acute experimental pancreatitis and in terms of its correction

Author: Fedorenko V.N.¹, Nadeev A.P.², Pustovetova M.G.³

Abstract

Disclosure of pathogenesis of acute pancreatitis is possible only at carrying out of experimental researches, which gives the opportunity to explore the pathological process and reliably estimate the effect of the treatment. The experimental model of acute pancreatitis in white rat of strain Wistar through the introduction of trypsin and snake venom Viper berus in the course of the general pancreatic flow was reproduced in this research, and also its correction with the usage of octreotide and serum against the poison of Vipera berus was made. Assessment of animals’ mortality and morphometric study of pathomorphological changes of the pancreas, the liver and the duodenum was made. Introduction of trypsin and snake venom led to the development of the changes, characteristic for the destructive hemorrhagic pancreatic necrosis. The usage of octreotide and serum against the poison of Vipera berus reduced the lethality of experimental animals and the severity of pathomorphological changes in the organs of pancreatoduodenal zone.

Key words

snake venom, octreotide, acute pancreatitis, liver, pancreas, serum against the poison of vipers, trypsin

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About Authors (Correspondence):

Fedorenko V.N. – candidate of medical sciences, junior researcher of central scientific-research laboratory, e-mail: sibbasic@gmail.com

Nadeev A.P. – doctor of medical sciences, professor of chair of pathologic anatomy, e-mail: nadeevngma@mail.ru

Pustovetova M.G. – doctor of medical sciences, professor of chair of normal physiology, chief of central scientific-research laboratory, e-mail: patophisiolog@mail.ru

Full Text

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Received: 09/02/2015