Content of matrix metalloproteinase-9 in the lacrimal and intraocular liquids in choroidal melanoma
Author Affiliations1Intersectoral Research and Technology Complex «Eye microsurgery» n.a. acad. S.N. Fyodorov of Minzdrav of Russia, Novosibirsk Branch, 630096, Novosibirsk, Kolkhidskaya str., 10
2Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
3Novosibirsk Affiliation of the Academician S.N. Fyodorov Federal State Budgetary Institution Intersectoral Research and Technology Complex «Eye microsurgery» of Minzdrav of Russia 630071, Novosibirsk, Kolkhidskaya str., 10
4Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasny av., 52
Abstract
The concentrations of matrix metalloproteinase-9 in the lacrimal and intraocular liquids in patients with choroidal melanoma have been investigated. The significant association between matrix metalloproteinase-9 concentrations in the lacrimal and intraocular liquids has been revealed. It has been shown that the development and growth of choroidal melanoma are associated with the increase in concentrations of matrix metalloproteinase-9 in the lacrimal and intraocular liquids in affected eye as well as in paired «healthy» eye. That indicates the pronounced proliferative processes at the local level.
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About Authors (Correspondence):
Chernyavskaya M.A. – postgraduate student of pathophysiological department, ophthalmologist, e-mail: mach.mntk@gmail.com
Efremov A.V. – honored scientist of the RF, corresponding member, professor, head of the department of pathophysiology, e-mail: eav48@yandex.ru
Chernykh V.V. – doctor of medical sciences, professor, director, e-mail: rimma@mntk.nsk.ru
Pustovetova M.G. – doctor of medical sciences, professor, head of central scientific research laboratory, e-mail: patophisiolog@mail.ru
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