Morphometric characteristics of the histopathological parameters of the bone tissue and articular surface of the femoral head in the coxarthrosis’ different nosological entities
Abstract
The present article is devoted to the examination of the morphometric characteristics of the histopathological parameters of the femoral head in coxarthrosis. According to the up-to-date perceptions, regardless of the etiological factor, the coxarthrosis has the similar clinical, pathogenetic and histopathological manifestations. Despite the histopathological construction patterns of the femoral head in coxarthrosis described in the fundamental works, many aspects of this problem are not yet completely detected. The aim of the study is the assessment of the histopathological patterns of the bony tissue and articular surface of the femoral head in the coxarthrosis’ different nosological entities. The study was performed on the operational material (head of femur) of 127 patients with clinically presented diagnosis “III-IV stages coxarthrosis”. The articular surface’s and subcartilaginous bony tissue’s fragment was carved of the obtained material, its sizes were 1.5х1.0х0.5 сm. Fixation and decalcination of the carved fragments were carried out in the EDTA solution. After decalcination there was a histological guiding of the material with its further encasement in a wax and making the histologic sections. The examination was performed using the light microscope. The mean age of the patients was 56,4 years (62 women, 65 men). Described in this article histopathological presentation of the structure of the articular surface and bony tissue of the femoral head in coxarthrosis does not contradict the earlier published research works. Due to the performed work the comparative morphometric characteristics of the histopathological indices of the bony tissue and articular surface of the femoral head in the coxarthrosis’ different nosological entities became possible. The following details were determined: the articular surface’s and bony tissue of the femoral head have a features sequence depending on the coxarthrosis’ nosological entity: self-existing coxarthrosis is characterized by dramatic thinning of the bone rods and decrease of their surfaces; in dysplastic coxarthrosis the articular surface is acutely thinned, expressed fibrosis of the bony tissue, the maximal thickness and space of the bone rods; post-traumatic genesis coxarthrosis is characterized maximally expressed fibrotic changes of the articular surface; the thickness of the articular surface is maximal in post-ischemic genesis coxarthrosis, аnd evidence of its fibrosis аnd bony tissue have the minimal manifestations.
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ReferencesDavydov D.A. – physician of pathologic anatomy department, e-mail: denis260586@rambler.ru
Avdalyan A.M. – doctor of the medical sciences, head of the laboratory
Agadzhanyan V.V. – doctor of the medical sciences, academician of RAS, head physician
Lushnikova E.L. – doctor of the biological sciences, director
Ust’yantseva I.M. – doctor of the biological sciences, head of the laboratory
