№ 2 / 2016 / 102-112

Comparative study of methods for correction of hemorrhagic syndrom in newborns and infants at the cardiac surgery

Author: Leonov N.P.¹, Karaskov A.M.², Strunin O.V.³

Abstract

Purpose of the study. Comparative study of methods for correction of hemorrhagic syndrome in newborns and infants was carried out at cardiac surgery as a result of a prospective study. Materials and methods. 120 patients were selected and randomized using the method of «envelopes» into two equal groups: using goal-oriented therapy and standard hemostatic therapy. Statistical comparisons of clinical and laboratory data were performed. Results and discussion. We have proved that the use of goal-oriented therapy twice reduces the severity of organ failure, reduces the severity of the hemorrhagic syndrome by 35 %, decreases the frequency of use (by 20–30 %) and volumes (by 50–60 %) of hemostatic drugs and blood products, shortens the duration of post-operative period by 30 % and increases the survival rate by 15 % as compared to the standard protocol of hemostatic therapy. The used protocol of the goal-oriented therapy can be recommended for clinical use in cardiac patients of this age group with bleeding.

Key words

hemorrhagic syndrome, infants, bleeding, newborns, thromboelastography, goal-oriented therapy

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About Authors (Correspondence):

Leonov N.P. – postgraduate student, anesthesiologist-intensivist of intensive care unit, e-mail: NikoLeonov@ya.ru

Karaskov A.M. – academician of RAS, doctor of medical sciences, professor, director

Strunin O.V. – doctor of medical sciences, anesthesiologist-intensivist, head of the intensive care unit

Full Text

16-2-2016.pdf

Received: 19/05/2016