The Siberian Scientific Medical Journal
№ 4 / 2016 / 45-50

Thymus after surgical removal of experimental tumors of mammary gland and chemotherapy

Author Affiliations


The histological study of changes in the thymus of female Wistar rats after breast tumor surgical removal (after 6 months from the start of the experiment) induced by intramammary administration of N-methyl-N-nitrosourea has been carried out. The structural features of the accidental involution formation manifested in a less pronounced way compared to the group with breast tumor without treatment have been revealed. The combination of lumpectomy with chemotherapy, compared to the group with the lumpectomy without chemotherapy causes the more pronounced thymus involution characterized by increased migration of lymphocytes from the thymus, delymphotization of morphofunctional zones of thymic parenchyma.

Key words

lymphocytes, oncology, thymus, surgery treatment, preventive treatment
About Authors (Correspondence):

Kazakov O.V. – candidate of biological sciences, leading researcher, e-mail:

KabakovA.V. – researcher, e-mail:

Poveshchenko A.F. – doctor of medical sciences, head of the laboratory, e-mail:

Lykov  A.P. – candidate of medical sciences, leading researcher, e-mail:

Rayter T.V. – postgraduate student, e-mail:

Strunkin D.N. – candidate of medical sciences, researcher, e-mail:

Ishchenko I.Yu. – candidate of medical sciences, senior researcher, e-mail:

Michurina S.V. – doctor of medical sciences, professor, chief researcher, e-mail:

Konenkov V.I. – doctor of medical sciences, academician of RAS, director,

Received: 31/08/2016