№ 2 / 2017 / 62-68

Significance of some modifiable risk factors for chronic non-communicable diseases on the formation of trans-systematic polymorbidity

Author: Sevostyanova E.V.¹, Nikolaev Yu.A.², Mitrofanov I.M.³, Polyakov V.Ya.⁴, Dolgova N.A.⁵, Gevorgyan M.M.⁶

Abstract

Purpose – to study the dependence of the frequency of occurrence and the values of indicators of basic risk factors for chronic non-communicable diseases on the degree of trans-systematic polymorbidity in patients of general therapeutic clinics. Material and methods. The analysis of 5013 medical records (2498 men, 2515 women) investigated and treated in the clinic of Research Institute of Experimental and Clinical Medicine (Novosibirsk) for the period from 2003 to 2013 was carried out. Trans-systematic polymorbidity was evaluated by the number of classes in a person in accordance with the International Classification of Diseases, 10th revision (ICD-10). The following risk factors were assessed according to clinical and laboratory tests: high blood pressure, obesity, increased concentration of total cholesterol, low density lipoprotein cholesterol, triglycerides, glucose, uric acid, decreased concentration of high density lipoprotein cholesterol in the blood. Results and discussion. Both among men and women with increasing index of trans-systematic polymorbidity there was identified growth of the indicators that determine the main non-communicable risk factors: systolic blood pressure, diastolic blood pressure, obesity, glucose, low density lipoprotein cholesterol, uric acid in the blood. The correlation analysis revealed a statistically significant direct correlation between the index of trans-systematic polymorbidity and parameters determining these risk factors. Thus there was established the influence of some of the basic hemodynamic and metabolic risk factors for chronic non-communicable diseases in the formation of trans-systematic polymorbidity. The findings indicate to the need for differentiated prevention and treatment of patients with polymorbidity with mandatory identification and correction of modifiable risk factors for chronic non-communicable diseases.

Key words

polymorbidity, risk factors, chronic non-communicable diseases

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About Authors (Correspondence):

Sevostyanova E.V. – candidate of medical sciences, senior researcher of laboratory for somatic diseases pathogenesis, e-mail: luck.nsk@rambler.ru

Nikolaev Yu.A. – doctor of medical sciences, deputy director on medical and scientific work, head of laboratory for somatic diseases pathogenesis, chief researcher, e-mail: nicol@soramn.ru

Mitrofanov I.M. – doctor of medical sciences, leading researcher of the laboratory for pathogenesis and somatic diseases, e-mail: mim@mail.ru

Polyakov V.Ya. – doctor of medical sciences, senior researcher of laboratory for somatic diseases pathogenesis, e-mail: vpolyakov15@mail.ru

Dolgova N.A. – chief physician, e-mail: novdolgova@yandex.ru

Gevorgyan M.M. – candidate of biological sciences, head of the clinical and biochemical laboratory, e-mail: gevorgyanmm@ngs.ru

Received: 25/04/2017