Mechanisms of abdominal sepsis formation at the peritonitis and strangulated intestinal obstruction

The mechanisms of abdominal sepsis forming at peritonitis and strangulated intestinal obstruction have been investigated with technetium-99m labeled Escherichia coli in the experimental work. It has been shown that the intestinal barrier is bacteria–tight in norm. Under conditions of widespread peritonitis the bacterial translocation and peritoneal resorption developed from the first minutes of the disease and the change of priority of bacteremia focuses from peritoneal to intestinal took place with the pathological process growth. The source of bacteremia development at strangulated intestinal obstruction is both microflora of strangulated loop of small gut and microflora of small intestine above the level of strangulation. Therewith the major role in bacteremia development and abdominal sepsis forming belongs to microflora of strangulated section of small intestine.

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Salato O.V. – candidate of medical sciences, junior researcher, e-mail: salatoov@mail.ru