Influence of the cannabinoid receptors synthetic ligands on eicosanoids synthesis in vitro

A dose-dependent effect of synthetic ligands of cannabinoid receptors (WIN 55.212-2 and anandamide) on the synthesis of leukotriene B₄ and tromboxane B₂ by blood cells in vitro was studied. It has been shown that WIN 55.212-2 and anandamide have a dose-depend effect of inhibition on the synthesis of leukotriene B₄ in whole blood in vitro. WIN 55.212-2 and anandamide have a maximum effect on the expression of leukotriene B₄ in a dose of 10 µM. The selective effect of WIN 55.212-2 and anandamide on the expression of oxylipins can be used for the development of immunomodulatory targeted pharmacological medicines.

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