The Siberian Scientific Medical Journal
 
 
№ 2 / 2012 / 5-8

Influence of the cannabinoid receptors synthetic ligands on eicosanoids synthesis in vitro

Author Affiliations

Abstract

A dose-dependent effect of synthetic ligands of cannabinoid receptors (WIN 55.212-2 and anandamide) on the synthesis of leukotriene B4 and tromboxane B2 by blood cells in vitro was studied. It has been shown that WIN 55.212-2 and anandamide have a dose-depend effect of inhibition on the synthesis of leukotriene B4 in whole blood in vitro. WIN 55.212-2 and anandamide have a maximum effect on the expression of leukotriene B4 in a dose of 10 µM. The selective effect of WIN 55.212-2 and anandamide on the expression of oxylipins can be used for the development of immunomodulatory targeted pharmacological medicines.

Key words

WIN 55.212-2, anandamide, immunocompetent cells, leukotriene B4, thromboxane B2
References
About Authors (Correspondence):

Lobanova E.G. – candidate of medical sciences, researcher of the laboratory of biomedical researches, e-mail: isachenko1@yandex.ru

Full Text

Received: 09/02/2015