The role of metabolic disorders in the risk of acute idiopathic deep venous thrombosis of the lower extremities development

Acute thrombosis of deep veins of the lower extremities (ATDVLE) is one of the most frequent causes of death and disability in Russia and industrialized world. The term "risk factors" is an integral part of the modern concept of acute deep venous thrombosis of the lower extremities. It defines any states when there is or is supposed the cause-and-effect relationship between their presence and the increased frequency of illness occurrence. Studies in recent years have uncovered many hemostatic and hemodynamic mechanisms of development of thrombophilic states. It is known less about the role of the "metabolic syndrome" concept in the development of acute disorders of venous circulation in the lower extremities. 80 patients with ATDVLE aged 18 to 59 years (48.3 ± 1.5 years) (38 men and 42 women) were examined. The monitoring group of 580 people (360 men, 220 women; the average age of 49.9 ± 0.5 years) was selected from the population-based samples of the residents of two administrative districts of Novosibirsk and investigated in the framework of the project HAPIEE. The frequency of metabolic syndrome and its components according to the criteria of GFCF and IDF were defined in patients with ATDVLE. The reliable association of metabolic syndrome with ATDVLE was found. It was diagnosed in 53.8 % of the patients and 28,8. % of the control group people (p < 0.05). Among the metabolic syndrome components the independent risk factors for ATDVLE are lipid metabolism disorders characterized by rising concentrations of triglycerides to 1.7 mmol/l in 76.2 % of patients and in 22.2 % of control group people (p < 0.05), LDL cholesterol >of 3.0 mmol/l in 47.4 % of patients and 26.7 % in the control group (p < 0.05) and the reduction of the concentration of HDL cholesterol < 1,0 mmol/l in men; HDL cholesterol < a 1.2 mmol/l in women of 43.7 % of patients with ATDVLE and 10.0 % in the control group (p < 0.05).

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Rоvenskikh D.N. - physician, surgeon-oncologist, e-mail: rovenskihd@mail.ru
Usov S.A. - doctor of medical sciences, professor
Voevoda M.I. - doctor of medical sciences, professor, corresponding member of RAS, director, e-mail: mvoevoda@ya.ru