The Siberian Scientific Medical Journal
 
 
№ 4 / 2014 / 115-121

Efficiency of combined therapy of anemia complicating pregnancy

Author Affiliations

Abstract

Study objective. To study the dynamics of the peripheral unit of erythron data of women with anemia complicating pregnancy, and without it under iron preparation monotherapy and combined therapy with iron in conjunction with release-active antibodies to erythropoietin. Materials and methods. The investigation and comparative assessment of peripheral unit of erythron indicators in 195 pregnant women with the moderate and severe degree of anemia and without it under monotherapy with Ferrum Lek alone and in combination with the Poetam preparation during the 8-week course of treatment have been carried out. Results and discussion. It was shown that the complex therapy of anemia of pregnancy with Poetam is more effective than the traditional method of treatment and promotes the earlier increase of red blood cells, hemoglobin, mean corpuscular volume and mean content of hemoglobin level. Activation of bone marrow erythropoiesis more expressed under combined action manifested in the increase of the number of peripheral blood reticulocytes. The data obtained shows the usefulness of prescription of release-active dilutions of antibodies to erythropoietin additionally to iron therapy of anemia of pregnant women.

Key words

аnemia, hemoglobin, peripheral link erythron, release activity, Ferrum Lek, eritropoietin, erythrocytes
References
About Authors (Correspondence):

Udut Ye.V. – doctor of medical sciences, leading researcher of laboratory of pathological physiology and experimental therapy, e-mail: evu8@mail.ru

Sotnikova L.S. – doctor of medical sciences, professor of the chair for obstetrics and gynecology of faculty training and postgraduate training, e-mail: sotnikova-larisa@mail.ru

Burmina Ya.V. – postgraduate student of laboratory of pathological physiology and experimental therapy, e-mail: burminay@gmail.com

Miroshnichenko L.A. – doctor of medical sciences, senior researcher of laboratory of pathological physiology and experimental therapy, e-mail: laarmi@rambler.ru

Simanina Ye.V. – candidate of medical sciences, senior researcher of laboratory of pathological physiology and experimental therapy, e-mail: laarmi@rambler.ru

Zyuz’kov G.N. – doctor of medical sciences, leading researcher of laboratory of Pathological physiology and experimental therapy, e-mail: zgn@pharm.tsu.ru

Zhdanov V.V. – doctor of medical sciences, professor, head of the laboratory of pathological physiology and experimental therapy, e-mail: zvv@pharm.tsu.ru

Chaykovskiy A.V. – candidate of medical sciences, researcher of laboratory of pathological physiology and experimental therapy, e-mail: thav_pharm@mail.ru

Stavrova L.A. – candidate of medical sciences, researcher of laboratory of pathological physiology and experimental therapy, e-mail: galao@sibmail.com

Full Text

Received: 08/02/2015