Composition of blood free and esterified fatty acids under the forming of metabolic syndrome
Author Affiliations1Vladivostok Affiliation of the Far Eastern Research Center of Physiology and Respiratory Pathology of the SB RAMS – Institute of Medical Climatology and Rehabilitation 690105, Vladivostok, Russkaya str., 73g
2Vladivostok Affiliation of the Far Eastern Research Center of Physiology and Respiratory Pathology of the SB RAMS – Institute of Medical Climatology and Rehabilitation 690105, Vladivostok, Russkaya str., 73g
3Institue of Marine Biology named after A.V. Zhirmunsky the FEB RAS 690059, Vladivostok, Palchevskogo str., 17
4Vladivostok Affiliation of the Far Eastern Research Center of Physiology and Respiratory Pathology of the SB RAMS – Institute of Medical Climatology and Rehabilitation 690105, Vladivostok, Russkaya str., 73g
5Vladivostok Affiliation of the Far Eastern Research Center of Physiology and Respiratory Pathology of the SB RAMS – Institute of Medical Climatology and Rehabilitation 690105, Vladivostok, Russkaya str., 73g
Abstract
The composition of plasma fatty acids, erythrocytes lipids, and the level of oxylipins in the blood serum of the patients with metabolic syndrome have been investigated. The increase of the polyunsaturated fatty acids level in blood plasma was detected while their simultaneous decrease in erythrocytes; high content of the leukotriene B4, thromboxane A2, 6-keto-prostaglandine-F1α was registered in the blood serum. The revealed modification of the composition of free and esterified fatty acids in blood plasma and cells, disorder of vasoactive and anti-inflammatory oxylipins synthesis are important pathogenetic link of metabolic syndrome development.
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About Authors (Correspondence):
Novgorodtseva T.P. – doctor of biological sciences, professor, deputy director for scientific work, head of the laboratory of biomedical researches, e-mail: curdeal@mail.ru
Karaman Yu.K. – candidate of biological sciences, senior researcher of the laboratory of biomedical researches, e-mail: karaman@inbox.ru
Zhukova N.V. – doctor of biological sciences, associated professor, senior researcher of the laboratory for comparative biochemistry, e-mail: nzhukova35@list.ru
Lobanova E.G. – candidate of medical sciences, researcher of the laboratory of biomedical researches, e-mail: isachenko1@yandex.ru
Antonyuk M.V. – doctor of medical sciences, head of the laboratory of the rehabilitative treatment, e-mail: antonyukm@mail.ru
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