The Siberian Scientific Medical Journal
 
 
№ 3 / 2014 / 48-55

Multipotent mesenchymal stromal cells for therapy of the limbal epithelium dysfunction

Author Affiliations

Abstract

One way of the limbal epithelial dysfunction therapy is the cellular therapy with stem cells. Multipotent mesenchymal stromal cells are a class of stem cells, which are distributed in the various tissues and organs. Multipotent mesenchymal stromal cells have the potential for self-maintenance, capable to differentiate under certain conditions into other types of cells. Multipotent mesenchymal stromal cells have reparative potential as well as immunomodulating, anti-inflammatory and modulating angiogenesis action. These potential properties of multipotent mesenchymal stromal cells are valuable for the reconstruction of the cornea. The information on the use of multipotent mesenchymal stromal cells for the treatment of disease of the cornea is summarized in the review.

Key words

cellular therapy, limbal stromal cells, multipotent mesenchymal stromal cells, regeneration, cornea, cytodifferentiation
References
About Authors (Correspondence):

Poveshchenko O.V. – candidate of medical sciences, head of the laboratory of cell technologies, e-mail: poveschenkoov@yandex.ru

Poveshchenko A.F. – doctor of medical sciences, head of the laboratory of physiology of the protective system, e-mail: poveshchenkoa200@mail.ru

Lykov A.P. – candidate of medical sciences, leading researcher of the laboratory of cell technologies, e-mail: lykovalex@freemail.ru

Bondarenko N.A. – candidate of biological sciences, junior researcher of the laboratory of cell technologies, e-mail: bond802888@yandex.ru

Niconorova Yu.V. – junior researcher of the laboratory of cell technologies, e-mail: jvnik@mail.ru

Druzhinin I.B. – candidate of medical sciences, ophthalmologist

Konenkov V.I. – academician of RAS, doctor of medical sciences, director, e-mail: lymphology@soramn.ru

Full Text

Received: 10/02/2015